Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows." --Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field." -- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis." --Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

• Section 1 Essentials of bone biology 1. The Biochemistry of Bone: Composition and Organization2. Bone Remodeling: Cellular Activities in Bone3. Assessment of Bone Turnover Using Biochemical Markers4. Fundamentals of Mineral Homeostasis5. The Mechanical Properties of Bone6. Assessment of Bone ArchitectureSection 2 Development and growth of the male skeleton7. Skeletal Growth in Males8. Pubertal Growth of the Male Skeleton9. The Effects of Sex Steroids on Bone Growth10. Nutritional Basis of Skeletal Growth 11. Physical Activity and Skeletal GrowthSection 3 Skeletal genetics12. The Genetics of Peak Bone Mass Section 4 Aging and the male skeleton13. Age-Related Changes in Bone Remodeling and Micro Architecture14. Markers of Bone Remodeling and the Aging Skeleton 15. Alterations in Mineral Metabolism in the Aging Male16. Change in Bone Size and Geometry with Aging17. Aging and Bone Density18. The Effect of Age on Material PropertiesSection 5 Nutritional issues19. Calcium, Bone Strength and Fractures20. Vitamin D and Bone21. Role of Dietary Protein in Bone Growth and Bone LossSection 6 Sex steroids and the skeleton in men22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes23. Estrogen and the Skeleton – Rodents24. Estrogen and the Skeleton – Humans25. Androgens and the Skeleton – Animal Models 26. Androgens and the Skeleton – Humans27. Androgen Effects on the Skeletal MuscleSection 7 Fractures in men28. Epidemiology of Fractures 29. Individualized Progress of Fractures in Men30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men31. Economic Impact of Osteoporotic Fractures (vs women)32. Adverse Health Outcomes in Men with OsteoporosisSection 8. Metabolic bone disease in men33. Idiopathic Osteoporosis34. Glucocorticoid Induced Osteoporosis35. Testicular Dysfunction36. Alcohol and Bone37. Transplantation Osteoporosis38. Management of Fractures in Men with Impaired Renal Function39. Hyperparathyroidism40. Hypercalciuria41. The Skeletal Phenotype of the Male Athlete42. Inherited and Related Disorders of Bone Matrix Synthesis in Men Section 9 Diagnostic approach43. Dual-Energy X-ray Absorptiometry (DXA) in Men44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men45. Advanced Structural Assessment of Bone Using CT and MRI46. Vertebral Fracture Assessments47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis48. Overall diagnostic strategySection 10 Therapy49. Diagnostic Thresholds for Osteoporosis in Men50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges51. Nutritional Therapy for Skeletal Health in Men52. Exercise Programs for Patients with Osteoporosis53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications54. Treatment of Male Osteoporosis with Bisphosphonates55. Treatment of Male Osteoporosis with Parathyroid Hormone56. Testosterone Therapy for Osteoporosis in Men57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows." --Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field." -- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis." --Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

• Section 1 Essentials of bone biology 1. The Biochemistry of Bone: Composition and Organization2. Bone Remodeling: Cellular Activities in Bone3. Assessment of Bone Turnover Using Biochemical Markers4. Fundamentals of Mineral Homeostasis5. The Mechanical Properties of Bone6. Assessment of Bone ArchitectureSection 2 Development and growth of the male skeleton7. Skeletal Growth in Males8. Pubertal Growth of the Male Skeleton9. The Effects of Sex Steroids on Bone Growth10. Nutritional Basis of Skeletal Growth 11. Physical Activity and Skeletal GrowthSection 3 Skeletal genetics12. The Genetics of Peak Bone Mass Section 4 Aging and the male skeleton13. Age-Related Changes in Bone Remodeling and Micro Architecture14. Markers of Bone Remodeling and the Aging Skeleton 15. Alterations in Mineral Metabolism in the Aging Male16. Change in Bone Size and Geometry with Aging17. Aging and Bone Density18. The Effect of Age on Material PropertiesSection 5 Nutritional issues19. Calcium, Bone Strength and Fractures20. Vitamin D and Bone21. Role of Dietary Protein in Bone Growth and Bone LossSection 6 Sex steroids and the skeleton in men22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes23. Estrogen and the Skeleton – Rodents24. Estrogen and the Skeleton – Humans25. Androgens and the Skeleton – Animal Models 26. Androgens and the Skeleton – Humans27. Androgen Effects on the Skeletal MuscleSection 7 Fractures in men28. Epidemiology of Fractures 29. Individualized Progress of Fractures in Men30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men31. Economic Impact of Osteoporotic Fractures (vs women)32. Adverse Health Outcomes in Men with OsteoporosisSection 8. Metabolic bone disease in men33. Idiopathic Osteoporosis34. Glucocorticoid Induced Osteoporosis35. Testicular Dysfunction36. Alcohol and Bone37. Transplantation Osteoporosis38. Management of Fractures in Men with Impaired Renal Function39. Hyperparathyroidism40. Hypercalciuria41. The Skeletal Phenotype of the Male Athlete42. Inherited and Related Disorders of Bone Matrix Synthesis in Men Section 9 Diagnostic approach43. Dual-Energy X-ray Absorptiometry (DXA) in Men44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men45. Advanced Structural Assessment of Bone Using CT and MRI46. Vertebral Fracture Assessments47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis48. Overall diagnostic strategySection 10 Therapy49. Diagnostic Thresholds for Osteoporosis in Men50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges51. Nutritional Therapy for Skeletal Health in Men52. Exercise Programs for Patients with Osteoporosis53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications54. Treatment of Male Osteoporosis with Bisphosphonates55. Treatment of Male Osteoporosis with Parathyroid Hormone56. Testosterone Therapy for Osteoporosis in Men57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows." --Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field." -- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis." --Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

• Section 1 Essentials of bone biology 1. The Biochemistry of Bone: Composition and Organization2. Bone Remodeling: Cellular Activities in Bone3. Assessment of Bone Turnover Using Biochemical Markers4. Fundamentals of Mineral Homeostasis5. The Mechanical Properties of Bone6. Assessment of Bone ArchitectureSection 2 Development and growth of the male skeleton7. Skeletal Growth in Males8. Pubertal Growth of the Male Skeleton9. The Effects of Sex Steroids on Bone Growth10. Nutritional Basis of Skeletal Growth 11. Physical Activity and Skeletal GrowthSection 3 Skeletal genetics12. The Genetics of Peak Bone Mass Section 4 Aging and the male skeleton13. Age-Related Changes in Bone Remodeling and Micro Architecture14. Markers of Bone Remodeling and the Aging Skeleton 15. Alterations in Mineral Metabolism in the Aging Male16. Change in Bone Size and Geometry with Aging17. Aging and Bone Density18. The Effect of Age on Material PropertiesSection 5 Nutritional issues19. Calcium, Bone Strength and Fractures20. Vitamin D and Bone21. Role of Dietary Protein in Bone Growth and Bone LossSection 6 Sex steroids and the skeleton in men22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes23. Estrogen and the Skeleton – Rodents24. Estrogen and the Skeleton – Humans25. Androgens and the Skeleton – Animal Models 26. Androgens and the Skeleton – Humans27. Androgen Effects on the Skeletal MuscleSection 7 Fractures in men28. Epidemiology of Fractures 29. Individualized Progress of Fractures in Men30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men31. Economic Impact of Osteoporotic Fractures (vs women)32. Adverse Health Outcomes in Men with OsteoporosisSection 8. Metabolic bone disease in men33. Idiopathic Osteoporosis34. Glucocorticoid Induced Osteoporosis35. Testicular Dysfunction36. Alcohol and Bone37. Transplantation Osteoporosis38. Management of Fractures in Men with Impaired Renal Function39. Hyperparathyroidism40. Hypercalciuria41. The Skeletal Phenotype of the Male Athlete42. Inherited and Related Disorders of Bone Matrix Synthesis in Men Section 9 Diagnostic approach43. Dual-Energy X-ray Absorptiometry (DXA) in Men44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men45. Advanced Structural Assessment of Bone Using CT and MRI46. Vertebral Fracture Assessments47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis48. Overall diagnostic strategySection 10 Therapy49. Diagnostic Thresholds for Osteoporosis in Men50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges51. Nutritional Therapy for Skeletal Health in Men52. Exercise Programs for Patients with Osteoporosis53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications54. Treatment of Male Osteoporosis with Bisphosphonates55. Treatment of Male Osteoporosis with Parathyroid Hormone56. Testosterone Therapy for Osteoporosis in Men57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon