Essential Concepts in Molecular Pathology

William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

"Essential Concepts in Molecular Pathology provides the reader with what is missing from most targeted introductions to pathology; the cell biology behind pathophysiology. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ; the text provides the student with the background necessary for the understanding of today’s advances in pathology and medicine. The book is compact, easy to follow, filled with useful tables and figures and deserves reading by students and professionals interested in the molecular basis of disease."--Howard Reisner PhD, Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, North Carolina, USA"Finally, a book that captures the real world environment of molecular diagnosis and pathology of a comprehensive range of diseases while establishing a foundation in the basics of molecular biology is available in Essential Concepts in Molecular Pathology! The clinical hospital laboratory has become a critical link in the rapidly changing way in which we diagnose disease with respect to molecular diagnostics. It has been challenging to embed the fundamentals of molecular diagnosis to students of clinical laboratory science (CLS) programs without a resource of the most current, state-of-the-art molecular foundations. Essential Concepts has not only offered an outstanding textbook to build future CLS practitioners, but it also represents an outstanding "working" resource for the established molecular pathologist and others involved biomedical research.  As the title states, the individual chapters relate the most important points about specific topics with excellent figures and examples while directing the user to Suggested Readings for more in-depth coverage. The editors have put together a wonderful resource for allied health programs and similar professionals to use as a textbook or as a companion to a more comprehensive molecular pathology offering."--Rodney E. Rohde, MS, SV, SM, MP (ASCP), Associate Professor, Texas State University-San Marcos, Clinical Laboratory Science, San Marcos, TX, USA

• PART I Essential Pathology - Mechanisms of Disease1 Cell Injury, Cell Death, and Cellular AdaptationJohn J. Lemasters, M.D., Ph.D. 2 Acute and Chronic InflammationVladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.3 Infection and Host ResponseSheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.4 NeoplasiaWilliam B. Coleman, Ph.D., and Tara Rubinas, M.D.PART II Concepts in Molecular Biology and Genetics5 Basic Concepts in Human Molecular GeneticsW. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.6 The Human Genome: Implications for the Understanding of Human DiseaseWilliam B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.7 The Human Transcriptome: Implications for the Understanding of Human DiseaseReinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.8 The Human Epigenome: Implications for the Understanding of Human DiseaseManel Esteller, Ph.D. and Maria Berdasco, Ph.D.9 The Human Proteome: Implications for the Understanding of Human DiseaseLance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin10 Integrative Systems Biology: Implications for the Understanding of Human DiseaseM. Michael Barmada, Ph.D. and David C. WhitcombPART III Principles and Practice of Molecular Pathology11 Pathology: The Clinical Description of Human DiseaseWilliam K. Funkhouser, M.D., Ph.D. 12 Molecular Pathogenesis: The Biological Basis of Human DiseaseWilliam B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D. 13 Integration of Molecular and Cellular PathogenesisJason H. Moore, Ph.D., and C. Harker Rhodes, M.D. PART IV Molecular Pathology of Human Disease 14 Molecular Basis of Cardiovascular DiseaseAvrum I. Gotlieb, M.D.C.M. and Amber Chang Liu15 Molecular Basis of Hemostatic and Thrombotic DiseasesNigel S. Key, M.D., and Alice Ma, M.D. 16 Molecular Basis of Lymphoid and Myeloid DiseasesDong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D. 17 Molecular Basis of Diseases of ImmunityDavid O. Beenhouwer, Ph.D. 18 Molecular Basis of Pulmonary DiseaseDani S. Zander, M.D., and Carol Farver, M.D. 19 Molecular Basis of Diseases of the Gastrointestinal Tract Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.20 Molecular Basis of Liver DiseaseSatdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.21 Molecular Basis of Diseases of the Exocrine PancreasMarkus M. Lerch, M.D. 22 Molecular Basis of Diseases of the Endocrine SystemMalcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D. 23 Molecular Basis of Gynecologic Diseases Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.24 Molecular Pathogenesis of Diseases of the KidneyAmy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.25 Molecular Basis of Prostate DiseaseWilliam G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.26 Molecular Basis of Breast DiseaseChristos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe BedardTranslational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium27 Molecular Basis of Skin DiseaseJohn A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D. 28 Molecular Basis of Diseases of the Nervous SystemJoshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.  PART V Practice of Molecular Medicine 29 Molecular Diagnosis of Human DiseaseGrant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D. 30 Molecular Assessment of Human Disease in the Clinical LaboratoryGregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.