Essential Concepts in Molecular Pathology

William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

"This is a well-illustrated, easy-to-read book perfectly geared toward aspiring and practicing pathologists. With the growing use of high throughput technologies by medical laboratories, clinicians increasingly rely on genomic, epigenomic, transcriptomic, and proteomic data to classify disease, predict patient outcomes, select therapy, and monitor response to treatment. This book illustrates how scientific discoveries have improved our understanding of disease and catalyzed the era of molecular-guided precision medicine. By highlighting landmark collaborative efforts like the Human Genome Project and new technologies on the horizon, it offers both historical and future-oriented perspectives on the rapidly growing field of genomic medicine. Overall, I would highly recommend this comprehensive textbook to those interested in molecular pathology." --Doody ReviewsPraise for the first edition:"The book is compact, easy to follow, filled with useful tables and figures and deserves reading by students and professionals interested in the molecular basis of disease." --Howard Reisner PhD, Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, North Carolina, USA"Finally, a book that captures the real world environment of molecular diagnosis and pathology…is available in Essential Concepts in Molecular Pathology! --Rodney E. Rohde, MS, SV, SM, MP (ASCP), Associate Professor, Texas State University-San Marcos, Clinical Laboratory Science, San Marcos, TX, USA

• PART I Essential Pathology - Mechanisms of Disease1. Molecular Mechanisms of Cell Death2. Acute and Chronic Inflammation3. Infection and Host Response4. NeoplasiaPART II Concepts in Molecular Biology and Genetics5. Basic Concepts in Human Molecular Genetics6. The Human Genome: Implications for the Understanding of Human Disease7. The Human Transcriptome: Implications for the Understanding of Human Disease8. The Human Epigenome: Implications for the Understanding of Human Disease9. Clinical Proteomics and Molecular Pathology10. Integrative Systems Biology: Implications for the Understanding of Human Disease11. Pathology: The Clinical Description of Human Disease12. Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease13. Integration of Molecular and Cellular PathogenesisPART IV Molecular Pathology of Human Disease14. Molecular Basis of Cardiovascular Disease15. Molecular Basis of Hemostatic and Thrombotic Diseases16. Molecular Basis of Lymphoid and Myeloid Diseases17. Molecular Basis of Diseases of Immunity18. Molecular Basis of Pulmonary Disease19. Molecular Basis of Diseases of the Gastrointestinal Tract20. Molecular Basis of Liver Disease21. Molecular Basis of Diseases of the Exocrine Pancreas22. Molecular Basis of Diseases of the Endocrine System23. Molecular Basis of Gynecologic Diseases 24. Molecular Pathogenesis of Kidney Diseases25. Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations26. Molecular Biology of Breast Cancer27. Molecular Basis of Skin Disease28. Molecular Pathology: NeuropathologyPART V Practice of Molecular Medicine 29. Molecular Diagnosis of Human Disease30. Molecular Assessment of Human Disease in the Clinical Laboratory31. Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease