Clusterin

Inbunden, Engelska, 2009

Del 104 i serien Advances in Cancer Research

1 800 kr

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Beskrivning

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Produktinformation

Utgivningsdatum:2009-11-23
Mått:152 x 229 x undefined mm
Vikt:590 g
Format:Inbunden
Språk:Engelska
Serie:Advances in Cancer Research
Antal sidor:350
Förlag:Elsevier Science
ISBN:9780123747723

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Recensioner i media

"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences."-- American Scientist"Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced."-- Journal of Medicinal Chemistry"This is a series that has a long tradition of excellence in the field of cancer biology."-- Doody's Publishing Reviews

Innehållsförteckning

. IntroductionSaverio Bettuzzi2. Clusterin (CLU): From One Gene and TwoTranscripts to Many ProteinsFederica Rizzi, Mariangela Coletta, and Saverio Bettuzzi3. The Shifting Balance Between CLU FormsDuring Tumor ProgressionSabina Pucci and Saverio Bettuzzi4. Regulation of Clusterin Activity by CalciumBeata Pajak and Arkadiusz Orzechowski5. Nuclear CLU (nCLU) and the Fate of the CellSaverio Bettuzzi and Federica Rizzi6. The Chaperone Action of Clusterin and Its Putative Rolein Quality Control of Extracellular Protein FoldingAmy Wyatt, Justin Yerbury, Stephen Poon,Rebecca Dabbs, and Mark Wilson7. Cell Protective Functions of SecretoryClusterin (sCLU)Gerd Klocks, Markus Baiersdo¨ rfer, and Claudia Koch-Brandt8. Clusterin: A Multifacet Protein at the Crossroad ofInflammation and AutoimmunityGe´ raldine Falgarone and Gilles Chiocchia9. Oxidative Stress in Malignant Progression: The Role of Clusterin,A Sensitive Cellular Biosensor of Free RadicalsIoannis P. Trougakos and Efstathios S. Gonos