Natural Hosts of SIV

Implication in AIDS

Inbunden, Engelska, 2014

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Beskrivning

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models
Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV
Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

Produktinformation

Utgivningsdatum:2014-08-06
Mått:152 x 229 x 25 mm
Vikt:860 g
Format:Inbunden
Språk:Engelska
Antal sidor:400
Förlag:Elsevier Science
ISBN:9780124047341

Utforska kategorier

Infektionssjukdomar och smittsamma sjukdomar inom Medicin
Onkologi inom Medicin
Biologi inom Naturvetenskap och teknik

Mer om författaren

Aftab Ansari, Ph.D. Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USAPh.D., University of Arizona, Tucson, Arizona, 1970 M.S., University of California, Los Angeles, CA, 1967 M.S., University of Karachi, Karachi, Pakistan, 1963 B.S., University of Karachi, Karachi, Pakistan, 1961 1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.2002-present Scientific Advisory Board, One World Health, San Francisco, CA.2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College, Nashville, TN2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health (CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices Panel Professor Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USAChief, Division of Microbiology and Immunology, Yerkes National Primate Research Center Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University

Innehållsförteckning

1. OverviewAftab Ansari and Guido Silvestri2. Historical perspectivePreston Marx3. SIV infections in the wildCristian Apetrei and Martine Peeters4. Virology of SIVsFrank Kirchhoff5. SIV infection of chimpanzeesJonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt6. Pathology of acute & chronic infectionFrancois Villinger and Sanjeev Gumber7. Mucosal immunityJason Brenchley8. Innate immunitySteven E. Bosinger and R. Keith Reeves9. Humoral immune responsesCynthia Ann Derdeyn and Reinhard Kurth10. Cellular immune responsesAmitinder Kaur11. Chronic immune activationDonald Sodora12. Pattern of infected cellsMirko Paiardini and Thomas Howerton Vanderford V13. Viral transmissionIvona Pandrea and Ann Chahroudi14. Genetics of the hostLutz Walter15. The different modes of HIV/SIV control in monkeys and humansLisa Chakrabarti16. Humans resembling natural hostsAmalio Telenti and Paul McLarenEpilogue: Implications for HIV infectionAftab Ansari and Guido Silvestri