Chesley's Hypertensive Disorders in Pregnancy

Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY. Previously, he was Professor of Obstetrics and Gynecology at The University of Utah, Wake Forest School of Medicine, Emory University, and Director of the Center for Reproductive Sciences at the University of California, San Francisco. Taylor received his undergraduate education at Stanford University and the combined MD-PhD at Baylor College of Medicine. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist whose major research foci have included the role of placental angiogenesis and endothelial cell activation in preeclampsia, and the molecular actions of estrogen and progesterone on endometrial differentiation and neuroangiogenesis as they relate to endometriosis. Dr. Taylor served on executive committees of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, the World Endometriosis Society and the California Institute for Regenerative Medicine. Dr. Roberts’ research is interdisciplinary and involves fundamental, clinical, behavioral and epidemiological studies. He has been involved in several seminal studies of preeclampsia including the recognition of preeclampsia as involving endothelial dysfunction and being more than hypertension in pregnancy. He currently is involved in global health research as part of the Global Pregnancy Collaboration, a consortium of 40 centers world-wide that facilitates collaborative research. He is a co-investigator on studies in Brazil and South Africa. He chaired the ACOG Hypertension Task Force and was co-chair of the NHLBI NIH workshop on research on pregnancy hypertension. F. Gary Cunningham, MD is holder of the Miguel and Beatrice Distinguished Chair of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center. He is also chair emeritus of the Department of Obstetrics and Gynecology, having served in that position for 22 years. Dr. Cunningham received his MD degree from the Louisiana State University School of Medicine and completed a residency in Obstetrics and Gynecology at Charity Hospital of New Orleans. Following this, he completed a fellowship in Maternal-Fetal Medicine at UT Southwestern and Parkland Hospital in Dallas, Texas. His early career was influenced by Dr. Jack Pritchard, and together they performed extensive clinical and laboratory research in preeclampsia and eclampsia, coagulopathies and other hematological complications of pregnancy, as well as a myriad of medical and surgical disorders complicating pregnancy. He has served as an examiner for the American Board of Obstetrics and Gynecology, served as tor for an NIH consensus conference, and is a member of the Society for Maternal-Fetal Medicine, Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society. Dr. Cunningham has served as senior editor of the 18th through 24th editions of Williams Obstetrics. Dr. Marshall Lindheimer, a professor (emeritus) of Medicine, Obstetrics & Gynecology, and Clinical Pharmacology at the University of Chicago is a longtime admirer and was a longtime friend of the late Leon Chesley. Chief Editor of the second and third editions of this text and leader of the search for its current chief editor, Dr. Lindheimer prefers to be called “editor emeritus” despite continuing to comment and publish in the area of the hypertension and renal disease in pregnancy. His CV contains over 400 publications including a monograph, other edited texts, reviews, text chapters and articles devoted to both basic and clinical research. Boarded in Internal Medicine and Nephrology, he is the recipient of many awards and honors that include an honorary membership in the Society of Maternal Fetal Medicine and an ad eundem of the Royal College of Obstetrics and Gynecology London. He has received an Honoris Causa degree from Bern University, the Chesley award from the International Society for the Study of Hypertension in Pregnancy, the Belding Scribner Award from the American Society of Nephrology and the Joseph Bolivar DeLee Humanitarian award from the Board of Directors at Lying-in Hospital, Chicago. Both the National Kidney Foundation of Illinois and the Preeclampsia Foundation have honored him as well. Of note on his wall is a congratulatory letter from President Obama, recognizing his accomplishments in regard to the health of pregnant women and their unborn children.

Praise for the Fourth Edition:"This book constitutes an indispensable update on preeclampsia, one of the most important and intriguing diseases of pregnancy. It covers the genetic, mechanistic, immunological and medical aspects of hypertension in pregnancy in a very comprehensive way. It is written clearly by world specialists in the subject, making it accessible to students, scientists and physicians as well." --Daniel Vaiman, PhD, HDR, Head Team "Genetics, Epigenetics, Physiopathology of Reproduction,"Co-Head, Department "Development, Reproduction, Cancer," Cochin Institute, INSERM, Cochin Hospital, Paris, France"Once again the editors of Chesley’s Hypertensive Disorders of Pregnancy have put together an outstanding team of contributors, combining investigators and clinicians, with expertise in preeclampsia to help elucidate our current understanding of this complex disorder. These contributors have put together an exemplary text that highlights recent basic science and clinical research as well as their implications for clinical care and future investigation. I suspect Dr. Chesley would be proud to see that his name continues to lead such an impressive tome." --Ira M. Bernstein, MD, John van Sicklen Maeck Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Science, College of Medicine, University of Vermont, Burlington, VT, USA"This 4th edition of Chesley’s classic textbook provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia, its most delicate condition. These range from the epidemiology to the molecular aspects, all analyzed from the background of normal pregnancy. Each chapter has been written by leaders in their respective areas, who discuss pioneering studies to still latent questions, simple interventions to sophisticated future tools, preconceptional management to the risks that mothers and offspring may face in later life. Clinical observations are conciliated with animal models and opposing hypotheses are united into continua (e.g., from an "underfilled" state in early pregnancy to an "overfill" in late pregnancy, from salt as a pressor element to an activator of the immune system). Putting into perspective the advancements made in the 47 years that separate this from the 1st edition illuminates the multiple achievements as well as the bridges that remain to be crossed. This text is a great way to honor the memory of Dr. Leon Chesley, the leader of this still open path, and should be obligatory reading for obstetricians, nephrologists, cardiologists and endocrinologists alike." --Gloria Valdes, MD, Professor, School of Medicine, Pontifi cia Universidad Católica, Santiago, Chile

• 1. Introduction, History, Controversies, and Definitions2. The Clinical Spectrum of Preeclampsia3. Epidemiology of Pregnancy-Related Hypertension4. Genetic Factors in the Etiology of Preeclampsia5. The Placenta in Normal Pregnancy and Preeclampsia 6. Angiogenesis and Preeclampsia7. Metabolic Syndrome and Preeclampsia8. Immunology of Normal Pregnancy and Preeclampsia 9. Endothelial Cell Dysfunction and Oxidative Stress10. Animal Models11. Tests to Predict Preeclampsia 12. Prevention of Preeclampsia and Eclampsia13. Cerebrovascular (Patho)Physiology in Preeclampsia/ Eclampsia 14. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy15. The Renin-Angiotensin Systems, their Autoantibodies, and Body Fluid Volume in Preeclampsia16. The Kidney and Normal Pregnancy and Preeclampsia 17. Platelets, Coagulation, and the Liver18. Chronic Hypertension and Pregnancy19. Antihypertensive Treatment 20. Management