Liver Regeneration

Basic Mechanisms, Relevant Models and Clinical Applications

Inbunden, Engelska, 2015

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Beskrivning

Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease.

By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management.

Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration.

Summarizes current liver regeneration studies and discussions on expected discoveries
Provides an overview of standard scientific and cutting-edge technologies to study liver regeneration
Presents details on the molecular mechanisms that affect liver regeneration
Highly illustrated, with hundreds of full-color, graphic photographs and illustrations to enhance the learning process

Produktinformation

Utgivningsdatum:2015-08-17
Mått:191 x 235 x 18 mm
Vikt:840 g
Format:Inbunden
Språk:Engelska
Antal sidor:326
Förlag:Elsevier Science
ISBN:9780124201286

Utforska kategorier

Hepatologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Mer om författaren

Dr. Apte is a toxicologist and a liver pathobiologists. His research is focused on mechanisms of liver regeneration, drug-induced liver injury, pathogenesis of liver cancer and effects of perfluorinated chemicals on the liver. Dr. Apte teaches toxicology to graduate students and medical students, and serves as a course director for two main toxicology courses in his department.Dr. Apte is also a board certified toxicologist and is a member of the US EPA's Scientific Advisory Committee on Chemicals (SACC).

Innehållsförteckning

Chapter 1. Introduction to Liver Regeneration: History and General PrinciplesChapter 2. Models to Study Liver RegenerationChapter 3. Alternative Models to Study Liver Regeneration: ZebrafishChapter 4. The Priming and Progression Theory of Liver RegenerationChapter 5. Primary and Secondary Mitogen Theory of Liver RegenerationChapter 6. Developmental Pathways in Liver RegenerationChapter 7. Mechanisms of Termination of Liver RegenerationChapter 8. Modulation of Extracellular Matrix During Liver RegenerationChapter 9. Role of ChemokinesChapter 10. Role of Nuclear ReceptorsChapter 11. Role of Developmental Morphogens in Liver RegenerationChapter 12. Regulation of Cell Cycle during Liver RegenerationChapter 13. Role of microRNAs and Long Non-Coding RNAs in Liver RegenerationChapter 14. Changes in Hepatocyte Ploidy during Liver RegenerationChapter 15. Role of Endothelial Cells in Liver RegenerationChapter 16. Use of Computational Biology, Omics Technologies to Understand Liver RegenerationChapter 17. Mitogen Induced Cell Proliferation in the LiverChapter 18. Effect of Nutritional Diversity on Liver RegenerationChapter 19. Introduction of Hepatic Progenitor CellsChapter 20. Cellular Transdifferentiation in the LiverChapter 21. Activation of Hepatic Progenitor Cells in Liver Regeneration After Chemical Injury to the LiverChapter 22. Hepatic Progenitor Cells and iPS Cells as a Source of Mature HepatocytesChapter 23. Progenitor Cell Transplantation: Experimental ModelsChapter 24. Liver Regeneration as a Therapy for Acute Liver FailureChapter 25. Liver Regeneration Following Liver TransplantationChapter 26. Hepatocyte Transplantation TherapyChapter 27. Liver Regeneration: The Biliary Perspective