Epigenetics and Dermatology

Inbunden, Engelska, 2015

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Beskrivning

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.

Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes
Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials
Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Produktinformation

Utgivningsdatum:2015-02-17
Mått:152 x 229 x 27 mm
Vikt:1 130 g
Format:Inbunden
Språk:Engelska
Antal sidor:520
Förlag:Elsevier Science
ISBN:9780128009574

Utforska kategorier

Medicinsk genetik inom Medicin
Dermatologi inom Medicin

Mer om författaren

Christopher Chang, MD, PhD, is Chief of Immunology, Allergy and Pediatric Rheumatology at Joe DiMaggio Children's Hospital and Memorial Healthcare System. He holds appointments as Professor of Medicine at the University of California, Davis, Professor of Allergy and Immunology at Nova Southeastern University, and Professor of Pediatrics at Florida Atlantic and Florida International Universities. His research focuses on immunodysregulation, primary immunodeficiencies, autoimmunity, epigenetics, atopic dermatitis, and food allergy, with a special interest in artificial intelligence in medicine. He serves as Medical Director of Pediatric Research at Joe DiMaggio Children's Hospital and is Editor-in-Chief of Clinical Reviews in Allergy and Immunology and the Journal of Evidence-based Integrative Medicine. He is a Fellow of the AAAAI and a Regent of the ACAAI.

Innehållsförteckning

1. Introduction to Epigenetics2. Laboratory Methods in Epigenetics3. Keratinocyte Differentiation and Epigenetics4. Fibroblast Differentiation and Epigenetics5. Epigenetic Modulation on Hair Follicle Stem Cells6. Epigenetics and the Regulation of Inflammation7. Malignant Transformation and Epigenetics8. Sirtuins and Epigenetics and Dermatology9. MicroRNAs in Skin Diseases10. Systemic Lupus Erythematosus11. Psoriasis12. Scleroderma13. Allergic and Inflammatory Skin Diseases14. Other Autoimmune Diseases15. Infectious Skin Diseases16. Melanoma17. Cutaneous T-cell Lymphoma18. Aging19. Diagnostic Techniques Employing Epigenetics20. Therapeutic Approaches using Epigenetics21. The Changing World and Epigenetics – How the Environment Influences Epigenetics