Epigenetics and Dermatology

Inbunden, Engelska, 2015

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Beskrivning

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.

Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes
Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials
Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Produktinformation

Utgivningsdatum:2015-02-17
Mått:152 x 229 x 27 mm
Vikt:1 130 g
Format:Inbunden
Språk:Engelska
Antal sidor:520
Förlag:Elsevier Science
ISBN:9780128009574

Utforska kategorier

Medicinsk genetik inom Medicin
Dermatologi inom Medicin

Mer om författaren

Dr Chang is the current Medical Director for Pediatric Immunology, Allergy and Rheumatology at Joe DiMaggio Children’s Hospital in Florida. At the same time, he serves as Associate Program Director for the Allergy Immunology Fellowship program at the University of California at Davis. Dr. Chang has previously been Chief of the Division of Allergy and Immunology at Thomas Jefferson University and Nemours Children’s Hospital in Philadelphia, PA and Wilmington, DE, respectively. He is a fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), and a member of the Clinical Immunology Society (CIS) and the American Association of Immunologists (AAI). He is Chair of the Core Curriculum, Education and Residency Review Committee of the AAAAI and Vice-chair of the Training Program Directors Committee of the ACAAI. He has over 100 original publications and has authored over 20 chapters in immunology, rheumatology and allergy books, and has also edited 2 books with a third on the way. He has over 30 years’ experience in the practice of Immunology and Allergy and has been involved in the education of future allergists and immunologists at the levels of the medical student, resident and fellow.

Innehållsförteckning

1. Introduction to Epigenetics2. Laboratory Methods in Epigenetics3. Keratinocyte Differentiation and Epigenetics4. Fibroblast Differentiation and Epigenetics5. Epigenetic Modulation on Hair Follicle Stem Cells6. Epigenetics and the Regulation of Inflammation7. Malignant Transformation and Epigenetics8. Sirtuins and Epigenetics and Dermatology9. MicroRNAs in Skin Diseases10. Systemic Lupus Erythematosus11. Psoriasis12. Scleroderma13. Allergic and Inflammatory Skin Diseases14. Other Autoimmune Diseases15. Infectious Skin Diseases16. Melanoma17. Cutaneous T-cell Lymphoma18. Aging19. Diagnostic Techniques Employing Epigenetics20. Therapeutic Approaches using Epigenetics21. The Changing World and Epigenetics – How the Environment Influences Epigenetics