Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson’s career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi’s research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.

• Part I. Alcohol and Neurological Dysfunction1. Acute Ethanol-Induced Changes in Microstructural and Metabolite Concentrations on the Brain: Noninvasive Functional Brain Imaging2. Prenatal Alcohol Exposure and Neuroglial Changes in Neurochemistry and Behavior in Animal Models3. Alcohol on Histaminergic Neurons of Brain4. Antenatal Alcohol and Histological Brain Disturbances5. Alcohol Intoxication and Traumatic Spinal Cord Injury: Basic and Clinical Science6. Visual and Auditory Changes After Acute Alcohol Ingestion7. Zebrafish Models of Alcohol Addiction8. Effect of Alcohol on the Regulation of α-Synuclein in the Human Brain9. Consumption of Ethanol and Tissue Changes in the Central Nervous System10. Ethanol Consumption and Cerebellar Disorders11. Gene Expression in CNS Regions of Genetic Rat Models of Alcohol Abuse12. Role of TLR4 in the Ethanol-Induced Modulation of the Autophagy Pathway in the Brain13. Ghrelinergic Signaling in Ethanol Reward14. Alcoholic Neurological Syndromes15. Frontal Lobe Dysfunction After Developmental Alcohol Exposure: Implications From Animal Models16. Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding17. Antioxidant Vitamins and Brain Dysfunction in Alcoholics18. Serotonin Deficiency and Alcohol Use DisordersPart II. Addictive Substances and Behavioral Health19. Functional Reorganization of Reward- and Habit-Related Brain Networks in Addiction20. Ethanol: Neurotoxicity and Brain Disorders21. Functionally Relevant Brain Alterations in Polysubstance Users: Differences to Monosubstance Users, Study Challenges, and Implications for Treatment22. Deep Brain Stimulation: A Possible Therapeutic Technique for Treating Refractory Alcohol and Drug Addiction BehaviorsPart III. Tobacco Smoking in Neuromodulation23. Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use24. Tobacco Smoke and Nicotine: Neurotoxicity in Brain Development25. Paradise Lost: A New Paradigm for Explaining the Interaction Between Neural and Psychological Changes in Nicotine Addiction Patients26. Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse27. Role of Basal Forebrain in Nicotine Alcohol Co-abuse28. Chronic and Acute Nicotine Exposure Versus Placebo in Smokers and Nonsmokers: A Systematic Review of Resting-State fMRI StudiesPart IV. Drugs of Abuse and Brain Structure and Function29. Novel Psychoactive Substances: A New Behavioral and Mental Health Threat30. Cholesterol and Caffeine Modulate Alcohol Actions on Cerebral Arteries and Brain31. Sleep, Caffeine, and Physical Activity in Older Adults32. Ketamine: Neurotoxicity and Neurobehavioral Disorders33. Left/Right Hemispheric “Unbalance” Model in Addiction

Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson’s career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi’s research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.

• Part I. Alcohol and Neurological Dysfunction1. Acute Ethanol-Induced Changes in Microstructural and Metabolite Concentrations on the Brain: Noninvasive Functional Brain Imaging2. Prenatal Alcohol Exposure and Neuroglial Changes in Neurochemistry and Behavior in Animal Models3. Alcohol on Histaminergic Neurons of Brain4. Antenatal Alcohol and Histological Brain Disturbances5. Alcohol Intoxication and Traumatic Spinal Cord Injury: Basic and Clinical Science6. Visual and Auditory Changes After Acute Alcohol Ingestion7. Zebrafish Models of Alcohol Addiction8. Effect of Alcohol on the Regulation of α-Synuclein in the Human Brain9. Consumption of Ethanol and Tissue Changes in the Central Nervous System10. Ethanol Consumption and Cerebellar Disorders11. Gene Expression in CNS Regions of Genetic Rat Models of Alcohol Abuse12. Role of TLR4 in the Ethanol-Induced Modulation of the Autophagy Pathway in the Brain13. Ghrelinergic Signaling in Ethanol Reward14. Alcoholic Neurological Syndromes15. Frontal Lobe Dysfunction After Developmental Alcohol Exposure: Implications From Animal Models16. Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding17. Antioxidant Vitamins and Brain Dysfunction in Alcoholics18. Serotonin Deficiency and Alcohol Use DisordersPart II. Addictive Substances and Behavioral Health19. Functional Reorganization of Reward- and Habit-Related Brain Networks in Addiction20. Ethanol: Neurotoxicity and Brain Disorders21. Functionally Relevant Brain Alterations in Polysubstance Users: Differences to Monosubstance Users, Study Challenges, and Implications for Treatment22. Deep Brain Stimulation: A Possible Therapeutic Technique for Treating Refractory Alcohol and Drug Addiction BehaviorsPart III. Tobacco Smoking in Neuromodulation23. Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use24. Tobacco Smoke and Nicotine: Neurotoxicity in Brain Development25. Paradise Lost: A New Paradigm for Explaining the Interaction Between Neural and Psychological Changes in Nicotine Addiction Patients26. Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse27. Role of Basal Forebrain in Nicotine Alcohol Co-abuse28. Chronic and Acute Nicotine Exposure Versus Placebo in Smokers and Nonsmokers: A Systematic Review of Resting-State fMRI StudiesPart IV. Drugs of Abuse and Brain Structure and Function29. Novel Psychoactive Substances: A New Behavioral and Mental Health Threat30. Cholesterol and Caffeine Modulate Alcohol Actions on Cerebral Arteries and Brain31. Sleep, Caffeine, and Physical Activity in Older Adults32. Ketamine: Neurotoxicity and Neurobehavioral Disorders33. Left/Right Hemispheric “Unbalance” Model in Addiction

Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson’s career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi’s research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.

• Part I. Alcohol and Neurological Dysfunction1. Acute Ethanol-Induced Changes in Microstructural and Metabolite Concentrations on the Brain: Noninvasive Functional Brain Imaging2. Prenatal Alcohol Exposure and Neuroglial Changes in Neurochemistry and Behavior in Animal Models3. Alcohol on Histaminergic Neurons of Brain4. Antenatal Alcohol and Histological Brain Disturbances5. Alcohol Intoxication and Traumatic Spinal Cord Injury: Basic and Clinical Science6. Visual and Auditory Changes After Acute Alcohol Ingestion7. Zebrafish Models of Alcohol Addiction8. Effect of Alcohol on the Regulation of α-Synuclein in the Human Brain9. Consumption of Ethanol and Tissue Changes in the Central Nervous System10. Ethanol Consumption and Cerebellar Disorders11. Gene Expression in CNS Regions of Genetic Rat Models of Alcohol Abuse12. Role of TLR4 in the Ethanol-Induced Modulation of the Autophagy Pathway in the Brain13. Ghrelinergic Signaling in Ethanol Reward14. Alcoholic Neurological Syndromes15. Frontal Lobe Dysfunction After Developmental Alcohol Exposure: Implications From Animal Models16. Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding17. Antioxidant Vitamins and Brain Dysfunction in Alcoholics18. Serotonin Deficiency and Alcohol Use DisordersPart II. Addictive Substances and Behavioral Health19. Functional Reorganization of Reward- and Habit-Related Brain Networks in Addiction20. Ethanol: Neurotoxicity and Brain Disorders21. Functionally Relevant Brain Alterations in Polysubstance Users: Differences to Monosubstance Users, Study Challenges, and Implications for Treatment22. Deep Brain Stimulation: A Possible Therapeutic Technique for Treating Refractory Alcohol and Drug Addiction BehaviorsPart III. Tobacco Smoking in Neuromodulation23. Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use24. Tobacco Smoke and Nicotine: Neurotoxicity in Brain Development25. Paradise Lost: A New Paradigm for Explaining the Interaction Between Neural and Psychological Changes in Nicotine Addiction Patients26. Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse27. Role of Basal Forebrain in Nicotine Alcohol Co-abuse28. Chronic and Acute Nicotine Exposure Versus Placebo in Smokers and Nonsmokers: A Systematic Review of Resting-State fMRI StudiesPart IV. Drugs of Abuse and Brain Structure and Function29. Novel Psychoactive Substances: A New Behavioral and Mental Health Threat30. Cholesterol and Caffeine Modulate Alcohol Actions on Cerebral Arteries and Brain31. Sleep, Caffeine, and Physical Activity in Older Adults32. Ketamine: Neurotoxicity and Neurobehavioral Disorders33. Left/Right Hemispheric “Unbalance” Model in Addiction