Bor-Sen Chen received B.S. degree of electrical Engineering from Tatung Institute of Technology in 1970, M.S. degree of Geophysics from National Central University in 1973, and PhD in Electrical Engineering from University of Southern California in 1982. He is an expert on the topic of nonlinear robust control and filter designs based on stochastic Nash game theory to override the influence of intrinsic random fluctuations and attenuate the effect of environmental disturbances, which can be applied to evolutionary game strategies of biological networks under natural selection to respond to random genetic variations and environmental disturbances in the evolutionary process. Prof. Chen had audited more than 10 courses of biology before his research in systems biology. He has published about 100 papers in bioinformatics and systems biology. Further, he have published more than 100 papers in system theory and control, and more than 80 papers of signal processing and communication. In the last three years, he has also published 7 monographs. He was elected to an IEEE Fellow in 2001 and became an IEEE Life Fellow in 2014. Cheng-Wei Li received the B.S. degree in automatic control engineering from Feng Chia University and the Ph.D. degree in electrical engineering from the National Tsing Hua University (NTHU), Hsinchu, Taiwan, in 2003 and 2010, respectively. He currently joins Dr. Bor-Sen Chen's lab at NTHU (2011-now) to conduct postdoctoral research in systems biology, and computational neuroscience. His research interests include systems biology, bioinformatics and stochastic nonlinear control.

• Chapter 1. Introduction to Big Mechanisms in Systems BiologyChapter 2. System Modeling and System Identification Methods for Big Mechanisms in Biological SystemsChapter 3. Procedure for Exploring Big Mechanisms of Systems Biology Through System Identification and Big Database MiningChapter 4. Big Cellular Mechanisms in the Cell Cycle by System Identification and Big Data MiningChapter 5. Big Regulatory Mechanisms in the Transcriptional Regulation Control of Gene Expression Using a Stochastic System Model and Genome-Wide Experimental DataChapter 6. Big Mechanisms of Information Flow in Cellular Systems in Response to Environmental Stress Signals via System Identification and Data MiningChapter 7. Big Offensive and Defensive Mechanisms in Systems Immunity From System Modeling and Big Data MiningChapter 8. Big Regeneration Mechanisms via Systems Biology and Big Database Mining MethodsChapter 9. Big Tumorigenesis Mechanisms in Systems Cancer Biology via Big Database Mining and Network ModelingChapter 10. Big Evolutionary Mechanisms of Network Robustness and Signaling Transductivity in Aging and Carcinogenic Process by System Modeling and Database MiningChapter 11. Big Mechanisms of Aging via System Identification and Big Database MiningChapter 12. Big Drug Design Mechanisms via Systems Biology and Big Database Mining

Bor-Sen Chen received B.S. degree of electrical Engineering from Tatung Institute of Technology in 1970, M.S. degree of Geophysics from National Central University in 1973, and PhD in Electrical Engineering from University of Southern California in 1982. He is an expert on the topic of nonlinear robust control and filter designs based on stochastic Nash game theory to override the influence of intrinsic random fluctuations and attenuate the effect of environmental disturbances, which can be applied to evolutionary game strategies of biological networks under natural selection to respond to random genetic variations and environmental disturbances in the evolutionary process. Prof. Chen had audited more than 10 courses of biology before his research in systems biology. He has published about 100 papers in bioinformatics and systems biology. Further, he have published more than 100 papers in system theory and control, and more than 80 papers of signal processing and communication. In the last three years, he has also published 7 monographs. He was elected to an IEEE Fellow in 2001 and became an IEEE Life Fellow in 2014. Cheng-Wei Li received the B.S. degree in automatic control engineering from Feng Chia University and the Ph.D. degree in electrical engineering from the National Tsing Hua University (NTHU), Hsinchu, Taiwan, in 2003 and 2010, respectively. He currently joins Dr. Bor-Sen Chen's lab at NTHU (2011-now) to conduct postdoctoral research in systems biology, and computational neuroscience. His research interests include systems biology, bioinformatics and stochastic nonlinear control.

• Chapter 1. Introduction to Big Mechanisms in Systems BiologyChapter 2. System Modeling and System Identification Methods for Big Mechanisms in Biological SystemsChapter 3. Procedure for Exploring Big Mechanisms of Systems Biology Through System Identification and Big Database MiningChapter 4. Big Cellular Mechanisms in the Cell Cycle by System Identification and Big Data MiningChapter 5. Big Regulatory Mechanisms in the Transcriptional Regulation Control of Gene Expression Using a Stochastic System Model and Genome-Wide Experimental DataChapter 6. Big Mechanisms of Information Flow in Cellular Systems in Response to Environmental Stress Signals via System Identification and Data MiningChapter 7. Big Offensive and Defensive Mechanisms in Systems Immunity From System Modeling and Big Data MiningChapter 8. Big Regeneration Mechanisms via Systems Biology and Big Database Mining MethodsChapter 9. Big Tumorigenesis Mechanisms in Systems Cancer Biology via Big Database Mining and Network ModelingChapter 10. Big Evolutionary Mechanisms of Network Robustness and Signaling Transductivity in Aging and Carcinogenic Process by System Modeling and Database MiningChapter 11. Big Mechanisms of Aging via System Identification and Big Database MiningChapter 12. Big Drug Design Mechanisms via Systems Biology and Big Database Mining

Bor-Sen Chen received B.S. degree of electrical Engineering from Tatung Institute of Technology in 1970, M.S. degree of Geophysics from National Central University in 1973, and PhD in Electrical Engineering from University of Southern California in 1982. He is an expert on the topic of nonlinear robust control and filter designs based on stochastic Nash game theory to override the influence of intrinsic random fluctuations and attenuate the effect of environmental disturbances, which can be applied to evolutionary game strategies of biological networks under natural selection to respond to random genetic variations and environmental disturbances in the evolutionary process. Prof. Chen had audited more than 10 courses of biology before his research in systems biology. He has published about 100 papers in bioinformatics and systems biology. Further, he have published more than 100 papers in system theory and control, and more than 80 papers of signal processing and communication. In the last three years, he has also published 7 monographs. He was elected to an IEEE Fellow in 2001 and became an IEEE Life Fellow in 2014. Cheng-Wei Li received the B.S. degree in automatic control engineering from Feng Chia University and the Ph.D. degree in electrical engineering from the National Tsing Hua University (NTHU), Hsinchu, Taiwan, in 2003 and 2010, respectively. He currently joins Dr. Bor-Sen Chen's lab at NTHU (2011-now) to conduct postdoctoral research in systems biology, and computational neuroscience. His research interests include systems biology, bioinformatics and stochastic nonlinear control.

• Chapter 1. Introduction to Big Mechanisms in Systems BiologyChapter 2. System Modeling and System Identification Methods for Big Mechanisms in Biological SystemsChapter 3. Procedure for Exploring Big Mechanisms of Systems Biology Through System Identification and Big Database MiningChapter 4. Big Cellular Mechanisms in the Cell Cycle by System Identification and Big Data MiningChapter 5. Big Regulatory Mechanisms in the Transcriptional Regulation Control of Gene Expression Using a Stochastic System Model and Genome-Wide Experimental DataChapter 6. Big Mechanisms of Information Flow in Cellular Systems in Response to Environmental Stress Signals via System Identification and Data MiningChapter 7. Big Offensive and Defensive Mechanisms in Systems Immunity From System Modeling and Big Data MiningChapter 8. Big Regeneration Mechanisms via Systems Biology and Big Database Mining MethodsChapter 9. Big Tumorigenesis Mechanisms in Systems Cancer Biology via Big Database Mining and Network ModelingChapter 10. Big Evolutionary Mechanisms of Network Robustness and Signaling Transductivity in Aging and Carcinogenic Process by System Modeling and Database MiningChapter 11. Big Mechanisms of Aging via System Identification and Big Database MiningChapter 12. Big Drug Design Mechanisms via Systems Biology and Big Database Mining