RNA Modification

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Dr Guillaume Chanfreau obtained his Bachelor Degree from Université Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Université Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3’-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression.

• 1. The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and DynamicsPaul F. Agris2. The evolution of multi-substrate specificity by RNA modification enzymesJuan Alfonzo3. TrmD: a methyl transferase for tRNA methylation with m1G37Ya-Ming Hou4. Structures and activities of the Elongator complex and its co-factorsBertrand Séraphin5. RNA pseudouridylation: Mechanism and FunctionYi-Tao Yu6. The activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAsEric Phizicky7. Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAsAnthony Henras8. Adenosine Deaminases acting on RNA (ADARsPeter Beal9. Modifying the message: computational and experimental techniques for mapping the mRNA epitranscriptomeBrian Gregory