Gradients and Tissue Patterning

Stephen J. Small is at Department of Biology, New York University, NY, USA James Briscoe is at The Francis Crick Institute, London, UK

"For me, this volume marks a substantial shift in the morphogen gradient concept. This has fundamental importance to our understanding of embryonic development and alerts us to the often-overlooked parameter of time in dynamic systems. While this revision has likely been emerging over the last nearly 10 years, it is not easily noticed by one not working directly in the field. Consequently, I appreciate the update this book provides." --Doody

• 1. Lighting up the central dogma for predictive developmental biologyHernan G. Garcia, Augusto Berrocal, Yang Joon Kim, Gabriella Martini and Jiaxi Zhao2. Optogenetic approaches to investigate spatiotemporal signaling during developmentKatherine W. Rogers and Patrick Müller3. A matter of time: Formation and interpretation of the Bicoid morphogen gradientAnqi Huang and Timothy E. Saunders4. Constraints and limitations on the transcriptional response downstream of the Bicoid morphogen gradientHuy Tran, Aleksandra M. Walczak and Nathalie Dostatni5. Formation, interpretation, and regulation of the Drosophila Dorsal/NF-ΚB gradientAllison E. Schloop, Prasad U. Bandodkar and Gregory T. Reeves6. The design and logic of terminal patterning in DrosophilaCelia M. Smits and Stanislav Y. Shvartsman7. Dynamic positional information: Patterning mechanism versus precision in gradient-driven systemsJohannes Jaeger and Berta Verd8. Intracellular morphogens: Specifying patterns at the subcellular scaleLars Hubatsch and Nathan W. Goehring9. Insights into mammalian morphogen dynamics from embryonic stem cell systemsElena Camacho-Aguilar and Aryeh Warmflash10. Control of size, fate and time by the Hh morphogen in the eyes of fliesDavid G. Miguez, Diana Garcia-Morales and Fernando Casares11. Genetic mechanisms controlling anterior expansion of the central nervous systemBehzad Yaghmaeian Salmani and Stefan Thor12. Temporal dynamics in the formation and interpretation of Nodal and BMP morphogen gradientsAndrew D. Economou and Caroline S. Hill13. Signaling regulation during gastrulation: Insights from mouse embryos and in vitro systemsSophie M. Morgani and Anna-Katerina Hadjantonakis14. Just passing through: The auxin gradient of the root meristemBruno Guillotin and Kenneth D. Birnbaum15. Small RNAs as plant morphogensSimon Klesen, Kristine Hill and Marja C.P. Timmermans