Dosage Form Design Parameters

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

• 1. Levels of solid state properties: Role of different levels during pharmaceutical development2. Polymorphism and its Implications in Pharmaceutical Product Development3. Basics of crystallization process applied in drug research4. Role of amorphous state in drug delivery5. Particulate level properties and its implications on product performance and processing6. Bulk level properties and its role in formulation development and processing7. Concepts of hypothesis testing and types of errors8. Experimental design and analysis of variance9. Basic concept and application of Sampling procedures10. Statistical techniques in Pharmaceutical Product Development11. Drug-excipient interaction and incompatibilities12. Documentation protocols in product development department including clinical records13. Correlation between in-vitro and in-vivo screens: Special emphasis on high throughput screening, high throughput pharmacokinetic analysis14. Sterilization of pharmaceuticals: Technology, Equipment and Validation15. Package development of pharmaceutical products: Aspects of packaging materials used for Pharmaceutical Products16. Package types for different dosage forms17. Food and drug laws effecting pharmaceutical product design, development and commercial manufacturing18. Guiding Principles for Human and Animal Research during pharmaceutical product development19. Applications of Computer in Pharmaceutical Product Development20. Patents and other intellectual property rights in drug delivery21. Computer Aided Prediction of Pharmacokinetic (ADMET) Properties22. Ethics and Legal Protection of Uses of Computer Applications in Pharmaceutical Research