Seldin and Giebisch's The Kidney

Dr. Robert J. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in internal medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the Medical School. He then moved to Yale as the Dean of Yale School of Medicine and is now Ensign Professor of Medicine and Cellular and Molecular Physiology at Yale.Dr. Michael Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in autosomal dominant polycystic kidney disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. He is currently C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology. Dr. Orson W. Moe received his MD degree from the University of Toronto, where he also did his internal medicine residency and clinical nephrology fellowship. Dr. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Dr. Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology. Dr. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto, where she completed her residency and served as Chief Medical Resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and postdoctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto’s Samuel Lunenfeld Research Institute. Dr. Quaggin now serves as Editor for Current Opinion in Nephrology and Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently, Charles Horace Mayo Professor of Medicine at Northwestern University and a Finnish Distinguished Professor (2012–17). Dr. Quaggin has been the recipient of many awards and honors.

• Volume 1Section I: Epithelial and nonepithelial transport and regulation1. Epithelial cell structure and polarity2. Mechanisms of ion and water transport across cell membranes and epithelia3. Renal ion-translocating ATPases4. Cell volume control5. Solute transport, energy consumption and production in the kidney6. Electrophysiological analysis of transepithelial transport7. Renal ion channels, electrophysiology of transport and channelopathies8. Microvascular permeability and the exchange of water and solutes across microvascular walls9. Renal cilia structure, function, and physiology10. Intercellular junctions and cell–matrix interactions11. Principles of cell signaling12. Scaffolding proteins in transport regulation13. The renin–angiotensin system14. Neural control of renal function15. Eicosanoids and renal function16. Extracellular nucleotides, metabolites, and renal functionSection II: Structural and functional organization of the kidney17. Structural organization of the mammalian kidney18. Biophysical basis of glomerular filtration19. Glomerular cell biology20. Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion21. Vasculature of the kidney cortex and medulla22. The development of the kidney23. Molecular and cellular mechanisms of glomerular capillary developmentSection III: Fluid and electrolyte regulation and dysregulation24. Epithelial Na + channels25. Anion channels26. Physiology and pathophysiology of the NaCl cotransporters in the kidney27. Balance and the pathophysiology of acid–base, fluid, and electrolyte disorders28. Sodium and chloride transport in the proximal tubule29. Mineralocorticoid action in the aldosterone-sensitive distal nephron30. Genetic disorders of renal salt homeostasis and blood pressure31. Pathophysiology of sodium retention and wastage32. Physiology and pathophysiology of hypertension33. Aquaporin water channels in mammalian kidney34. Thirst and vasopressin35. The urine-concentrating mechanism and urea transporters36. Hyponatremia37. Hypernatremic states38. The function and regulation of renal K + channels39. Extrarenal potassium metabolism40. Regulation of K⁺ excretion41. Physiopathology of potassium deficiency42. Clinical disorders of hyperkalemiaVolume 2Section III: Fluid and electrolyte regulation and dysregulation (contd)43. Intracellular pH homeostasis44. SLC4 sodium-coupled bicarbonate and carbonate transporters45. Anion exchangers of the SLC4 gene family46. Cellular mechanisms of renal tubular acidification47. Renal ammonium ion production and transport48. Clinical syndromes of metabolic alkalosis49. Clinical syndromes of metabolic acidosis50. Respiratory acid–base disorders51. Mechanisms and disorders of magnesium metabolism52. Calcium channels53. The calcium-sensing receptor54. Renal calcium metabolism55. Kidney stones56. Proximal tubular handling of phosphate57. Clinical disturbances of phosphate homeostasis58. Glucose reabsorption in the kidney59. Kidney transport of amino acids and oligopeptides and aminoacidurias60. Renal filtration, transport, and metabolism of albumin and albuminuriaSection IV: Pathophysiology of renal disease61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid–base disorders62. Acute kidney injury biomarkers63. Pathophysiology of acute kidney injury64. Ischemic renal disease65. Pathophysiology and pathogenesis of diabetic kidney disease66. Autosomal dominant polycystic kidney disease67. Renal physiology and disease in pregnancy68. Glomerular disorders69. Immunologic mechanisms of vasculitis70. Genetic abnormalities in glomerular function71. Mechanisms of drug nephrotoxicity72. Role of proteinuria in the progression of renal disease73. Oxidative stress and signaling in renal physiology and kidney diseases74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient76. Mechanisms of allograft rejection77. Homeostasis of solute and water by the transplanted kidney