Toxicology Cases for the Clinical and Forensic Laboratory

Dr. Hema Ketha completed her post-doctoral research training at the Mayo Clinic in Rochester, MN focusing on areas exploring the role of vitamin D physiology in bone and kidney diseases, protein purification and protein interactions, mouse model studies of bone disease and development, validation and clinical implementation of liquid chromatography with tandem mass spectrometry (LC-MS/MS) analytical methods for vitamin D metabolic profiling. Then she pursued post-doctoral clinical training in clinical chemistry at the Mayo Clinic before joining the Department of Pathology at the University of Michigan. She is currently a Technical Director, Toxicology and Mass Spectrometry, LabCorp, Burlington, NC. Her research interests are in clinical endocrinology, toxicology and clinical LC-MS/MS. She has won several awards from professional organizations including the AACC and ACLPS for her work in the areas of clinical chemistry and clinical mass spectrometry. She has research interests in areas of clinical endocrinology, toxicology and clinical LC-MS/MS. Additionally, she works on evaluating various immunoassays for current send-out esoteric analytes that can be validated and implemented at Michigan’s clinical laboratory. She has authored peer-reviewed publications and won several awards from professional organizations including the AACC and ACLPS for her work in the areas of clinical chemistry and clinical mass spectrometry. Dr. Uttam Garg has published over 150 research papers, review articles, and book chapters in the area of clinical biochemistry, therapeutic drug monitoring and toxicology, and Co-Edited a book on Clinical Applications of Mass Spectrometry. His research interests include methods development in clinical laboratory diagnosis. His research interests include clinical method development on a variety of diagnostic platforms including mass spectrometry. He received his Ph.D. in Experimental Medicine from the Postgraduate Institute of Medical Education and Research in India. He received his postdoctoral training in Pharmacology at and Clinical Chemistry at New York Medical College and University of Minnesota Medical School respectively. Before joining his current position, he served as faculty at the NYU Medical Center and the University of Minnesota Medical School.

• SECTION I - Basic Principles1. An Introduction to Clinical and Forensic Toxicology2. Pharmacokinetics and Pharmacodynamics3. Laboratory Methods in Toxicology4. Management of an Overdose Patient5. Alcohols: Volatiles and GlycolsSECTION II – Overview and Case Studies6. Analgesics and Anti-inflammatory Drugs7. Antibiotics8. Antidepressants and Antipsychotics9. Anticonvulsants10. Antineoplastic Drugs11. Cannabinoids12. Cardiotoxicity13. CNS Depressants: Benzodiazepines and Barbiturates14. CNS Stimulants15. Designer Drugs16. Hallucinogens and Psychedelics17. Immunosuppressive Drugs18. Opioids19. Toxic Herbals and Plants in U.S. 20. Toxic Gases21. Toxic Metals 22. Venoms and Pesticides23. Case Studies on Other Drugs