Endothelial Signaling in Vascular Dysfunction and Disease

Shampa Chatterjee is Associate Professor at the Department of Physiology, University of Pennsylvania School of Medicinein Philadelphia. Trained in India, Germany and the US, her current research is on inflammation-immune signaling with a focus on the vascular system. Her lab studies the role of redox signals in the onset and amplification of inflammation and immune responses. Toward this, recent work from her group showed that the systemic cytokine storm associated with COVID-19 activates an inflammation cascade in the vascular system that can potentially lead to vascular dysfunction. Research in her lab is funded by extramural research funding from the NIH and corporate sources. Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology. She has published more than 100 papers in peer reviewed journals and edited two books on Endothelial Signaling, and on Inflammation and Immune responses. Dr. Chatterjee has received numerous awards such as the Caroline Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology. The topics addressed in this book are central to her research where she tries unraveling the balance between the onset of inflammation in host protection and resolution of inflammation in host injury.

• Part I. The Vascular Tree as an Integrative Structure 1. The Vascular System: Components, Signaling and Regulation2. ROS-induced ROS release in Vascular Signaling and Disease3. Nitric oxide as a vascular modulator to resistance training 4. Reactive Oxygen Species (ROS), Redox signaling and Regulation of Vascular Endothelial SignalingPart II: The Endothelium in Inflammation: Signaling for Vascular Disease5. Inflammation and Coronary Artery Disease6. An activated endothelium post Organ Transplantation: The Pathogenesis of Rejection7. Neurovascular Unit: Intercellular Signaling and Translational SignificancePart III. Endothelial Signaling, Activation and Toxicity with Chemotherapy 8. Signaling in the Tumor Vasculature 9. Chemotherapy induced Vascular Changes: Onset of Various Pathologies10. Role of Angiogenesis in Wound Healing: Their impact in Acute and Chronic Wound Healing11. Normalization of the Tumor Vasculature 12. VEGF/VEGFR signaling in regulation of innate and adaptive immunity in solid tumors Part IV: Radiation Induced Endothelial Dysfunction and Vascular Disease13. Human Radiation Exposures (Occupational, Medical, Environmental and Radiation Incidents) and Vascular Dysfunction14. Flow adapted vascular systems: Mimicking the vascular network to predict clinical response to radiation 15. Radiotherapy and its effects on the tumor and normal vasculature 16. Effects of space radiation on the pulmonary endovasculature: implications for future human deep space exploration17. Role of endothelial cells in normal tissue radiation injuryPart V: Therapies in Combating Vascular Diseases18. Experimental Models for Identifying Target Events in Vascular Injury19. Hemeoxygenase and its Metabolites in Regulation of Vascular Endothelial Health20. The endothelium as a target for bacterial infection RBC Conjugated agents in Prophylaxis: Challenges at the Bedside21. Stents versus Scaffolds: Various Tools in Percutaneous Coronary Interventions22. Statins in Deep Vein Thrombosis: Biochemical Approaches to limiting vascular Disease23. Mathematical modeling approaches in understanding endothelial function24. Endothelial dysfunction and vascular diseases. Uric acid and Oxidative stress25. Comparative Assessment of Electrocardiographic Parameters of Some Birds -An Essential Diagnostic Tool in Veterinary practice26. Conclusions, Future perspectives and Shifting paradigms in Endovascular Biology From The Editor’s Desk