GPCRs

Dr. Beata Jastrzebska is an Assistant Professor in the Department of Pharmacology, School of Medicine, Case Western Reserve University, Ohio. Her lab focuses on understanding the structure and function of the visual G protein coupled receptor (GPCR), rhodopsin. In particular, she is interested in delineating the rhodopsin supramolecular organization and its implications for binding with the cognate heterotrimeric G protein, transducin. Several mutations identified in the rhodopsin gene leading to the retinal degeneration in humans, such as retinitis pigmentosa (RP), could affect membrane oligomeric organization of this receptor. Therefore, efforts are directed towards understanding the molecular basis of rhodopsin gene associated retinal degradation in humans using biochemical, biophysical, and structural methods. Dr. Jastrzebska has published her research widely in peer reviewed journals and serials, including Biochemistry, Methods in Molecular Biology, JACS, and Methods in Enzymology. Dr. Park is an Associate Professor at the Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Ohio. He serves as Principle Investigator at the Park Lab, which focuses on molecular mechanisms underlying phototransduction and the determinants of photoreceptor cell health in the retina. Dr. Park and his team use advanced microscopy and spectroscopy methods in combination with more traditional biochemistry, microscopy, and cell biology methods. Dr. Park has published his research widely in peer reviewed journals, including Biochemistry, the Journal of Biological Chemistry, the Journal of Cell Biology, the Journal of Molecular Biology, and the European Journal of Pharmacology

• Part I GPCR structure1. Progress in GPCR structure Determination2. Structure, function and therapeutic potential of adhesion GPCRs3. Structural diversity in ligand recognition by GPCRs4. NMR-based approaches to the study of GPCRs and GPCR-ligand interactions5. Supramolecular structure of opsins6. Molecular determinants of GPCR oligomerization7. Structure of G-protein-coupled receptor heteromers8. Class A GPCR oligomerization: reasons of controversyPart II GPCR function9. Quantifying GPCR allostery and biased signaling10. Kinetics of ligand binding and signaling11. Allosteric modulators targeting GPCRs12. Arrestin-mediated signaling at GPCRs13. Organellar Gbγ signaling - GPCR signaling beyond the cell surfacePart III GPCRs in disease and targeted drug discovery14. G protein-coupled receptor allosteric modulators: understanding modulator affinity and pharmacological dose15. Computer-aided GPCR drug discovery16. Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches17. G protein-coupled receptors in neurodegenerative diseases18. GPCR targets in type 2 diabetes19. GPCRs in thromboinflammation and hemostasis20. Angiotensin II receptors: structure-function and drug discovery21. GPCRs in innate and adaptive immune responses22. Role of GPCRs in cancer