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    1. Medicin
    2. Andra medicinska specialiteter
    3. Farmakologi

    Cancer-Leading Proteases

    Structures, Functions, and Inhibition

    AvSatya Prakash Gupta

    Häftad, Engelska, 2020

    1 521 kr

    Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers.

    In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.



    • Explains the role of proteases in the biology of cancer
    • Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers
    • Covers a wide range of cancers and provides detailed discussions on protease examples

    Produktinformation

    • Utgivningsdatum:2020-01-16
    • Mått:152 x 229 x undefined mm
    • Vikt:810 g
    • Format:Häftad
    • Språk:Engelska
    • Antal sidor:523
    • Förlag:Elsevier Science
    • ISBN:9780128181683

    Utforska kategorier

    • Farmakologi inom Medicin
    • Tillverkningsindustri inom Ekonomi och Ledarskap

    Mer om författaren

    Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers’ Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.

    Innehållsförteckning

    • 1. Proteases and Their Biological Roles and Mechanism of Action2. Specificity and Diversity in Proteases3. Potential Roles of Protease Inhibitors in Cancer Progression4. Serine Proteases in Ovarian Cancer5. Aspartic Proteases as Potential Drug Targets for Anticancer Drug Development6. Design and Development of Serine Proteases Acting against Prostate Cancer7. Urokinase and Colorectal Carcinoma: Studies on Mechanism and Inhibition8. Overexpression of Cystein Proteases and Colorectal Carcinoma9. Studies on Cystein Proteases and Their Inhibitors for Anti-cancer Drug Design10. Gelatinases and Anticancer Drug Development11. HCV NS3 Serine Protease as a Drug Target for Development of Drugs Against Liver Cancer12. Molecular Imaging of Proteases in Cancer