Organ Repair and Regeneration

Giuseppe Orlando, MD, PhD, Marie Curie Fellow, is an Associate Professor and a kidney and pancreas transplant surgeon scientist at the Wake Forest University School of Medicine, in Winston Salem, USA. His research aims at developing platforms for the bioengineering and regeneration of transplantable organs, and at developing therapies to enhance the innate ability of the human body to repair itself after damage. His literature output aims at bridging organ transplantation to regenerative medicine. Dr. Shaf Keshavjee completed his medical training at the University of Toronto in 1985, and subsequently trained in General Surgery, Cardiac Surgery and Thoracic Surgery at the University of Toronto followed by fellowship training at Harvard University and the University of London for airway surgery and heart-lung transplantation, respectively. He currently leads a team whose studies in transplantation will have a significant impact on treatment outcomes for patients with lung disease at UHN and around the world. Dr. Keshavjee was appointed UHN’s Surgeon-in-Chief in 2010.An integral part of the Division of Thoracic Surgery at UHN, Dr. Keshavjee has taken on leadership roles in all facets of this specialized area of care: as a skilled surgeon and Director of the Toronto Lung Transplant Program; and as a researcher and Director of the Latner Thoracic Surgery Research Laboratories. To improve lung function after transplantation, Dr. Keshavjee has developed a lung preservation solution to preserve donor lungs en route to transplant. This solution has become the standard technique used by transplantation programs around the world. Dr.Keshavjee has further attracted worldwide attention for his pioneering research to recondition and repair injured human donor lungs using a combination the Toronto XVIVO Lung Perfusion System, making them suitable for transplantation into patients and enhancing the number of donor lungs that are available. Dr. Keshavjee has served on the Board of Directors of the International Society for Heart and Lung Transplantation, The Canadian Society of Transplantation and on the Governing Council of the American Association for Thoracic Surgery. He has received numerous awards for his continuing contributions to his field, including the George Armstrong Peters Young Investigator Award, Canada’s Top 40 Under 40Award, the Colin Woolf Award for Excellence in Continuing Medical Education and the highest award for research achievement in the Department of Surgery: the Lister Prize in Surgery.

"The book is written in a comprehensive, yet digestible manner and meets its objectives. It is a unique and needed contribution to the field." --© Doody’s Review Service, 2021, Kelly M. Collins, MD(Henry Ford Hospital) reviewer, expert opinion"This book demonstrates the merging of regenerative medicine and organ transplantation. Key Features: Covers all aspects of organ preservation, repair and regeneration; Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ; Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine." --Anticancer Research"This is the latest in a series of textbooks published by Academic Press/Elsevier, edited or co-edited by Dr. Giuseppe Orlando, in the broad field of organ transplantation and covering all aspects of organ regeneration, from technological advances in organ preservation and reperfusion to regenerative medicine [1–3]. Orlando is a kidney and pancreas transplant surgeon from Wake Forest University, a unique environment in which a strong transplant programme coexists with a world-renowned institute of regenerative medicine, led by Dr. Anthony Atala. Organ Repair and Regeneration is a 289-page book co-edited by Orlando and Dr. Shaf Keshavjee, who has been a pioneer in the reconditioning of marginal lung grafts. The book is divided into 14 chapters written by authors from North America, Europe and Australia. In his foreword to this book, Dr. Atala sets the stage for what readers can expect from this book: ‘...we have developed a surrogate field of science called ‘organ preservation’ that –to the editors of this book – represents the most formidable platform nowadays for the application of regenerative medicine technologies in transplant medicine’ [4]. The book is divided into 14 chapters that can each be read as an independent review article. It is introduced by a chapter describing the concepts and molecular mechanisms of ischaemia-reperfusion injury that will be a reference for all further chapters of the book." --Transplant International

• 1. Ischemia-reperfusion injuryJENNIFER LI, NATASHA M. ROGERS, AND WAYNE J. HAWTHORNE2. Machine perfusion for donor organ repair: from vision to everyday clinical practiceMASATO FUJIYOSHI, VINCENT E. DE MEIJER, AND ROBERT J. PORTE3. Assessing and reconditioning kidneys using normothermic machine perfusionFANOURIOS GEORGIADES, SARAH A. HOSGOOD, AND MICHAEL L. NICHOLSON4. Autologous cells for renal allograft repairMARK CLANCY5. Repairing organs with MSCLAUREN BRASILE6. Resuscitation of the pancreas: whole organ and islet cell technologies into the machine eraAHMER HAMEED AND WAYNE J. HAWTHORNE7. Assessment of extended criteria liver grafts during machine perfusion. How far can we go?LAURA IOANA MAZILESCU AND MARKUS SELZNER8. RNA interference in organ transplantation: next-generation medicine?ISABEL M.A. BR€UGGENWIRTH AND PAULO N. MARTINS9. Repairing cardiac allografts on ex situ perfusion devicesS.E. SCHEUER, P.S. MACDONALD, AND K. DHITAL10. Repairing cardiac allografts in situOSCAR ZOU, SIMON MESSER, AND STEPHEN LARGE11. Steatotic livers for transplantation: improving utilization of a prevalent resource through organ repairSIAVASH RAIGANI, AYLIN ACUN, BASAK UYGUN, KORKUT UYGUN, AND HEIDI YEH12. Implementing the vision: the organ repair centerSHAF KESHAVJEE13. Mitochondria transplantation in organ damage and repairANDREA ROSSI, PAOLO PORPORATO, AND BENEDETTA BUSSOLATI14. How the transplant landscape is changing in the regenerative medicine eraPAULA A. GRISALES, JUSTINE M. AZIZ, SEAN M. MUIR, DOMENICA I. MARINO, CATHERINE LA POINTE, AMISH ASTHANA, AND GIUSEPPE ORLANDO