Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.

Covers physical, dietary and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging
Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia
Presents a clear definition of sarcopenia, along with the latest research in one volume

Produktinformation

Utgivningsdatum:2021-07-23
Mått:191 x 235 x 18 mm
Vikt:700 g
Format:Häftad
Språk:Engelska
Antal sidor:342
Förlag:Elsevier Science
ISBN:9780128221464

Utforska kategorier

Fysiologi inom Medicin
Endokrinologi inom Medicin

Mer om författaren

Professor Kunihiro Sakuma is a Physiologist working in the field of skeletal muscle at the Tokyo Institute of Technology in Japan. He began his scientific career in the Department of Physiology, Aichi Human Science Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and the attenuating strategy of sarcopenia (age-related muscle atrophy). Preventing sarcopenia is critical for maintaining a high quality of life in the aged population.

Innehållsförteckning

1. The definition of sarcopenia and the physical measures being associated with sarcopenia2. Mitochondrial dysfunction linking to sarcopenia3. The regulation of MicroRNA for sarcopenia4. The relationship between neuromuscular junction and sarcopenia5. The functional role of satellite cells in sarcopenic muscle6. The molecular mechanisms of age-related anabolic resistance7. The autophagic defect in sarcopenic muscle8. Mitophagy system in sarcopenic muscle9. Sarcopenia and the inflammatory cytokines10. Skeletal muscle ECM remodeling and sarcopenia11. Underlying mechanisms of sarcopenic obesity12. Dysphagia in sarcopenia and cachexia13. Under adjustment14. Molecular mechanism of exercise for combating sarcopenia15. Dietary approaches to maintain muscle mass16. Pharmacological strategy for sarcopenia17. Stem cells and sarcopenia with some translational aspect18. Metabolic reprogramming attenuating sarcopenia