Nadine Attal, MD, PhD, is a neurologist, Professor of Therapeutics and Pain Medicine at Paris Saclay University, head of The Pain Center at Hôpital Ambroise Paré, Boulogne-Billancourt, France and associate director of the U 987 INSERM research Unit. She has played a leading role in translational research in pain and has published in leading journals. She is section editor for BJA and PainReports and Councilmember of the International Association for the Study of Pain. She was appointed “chevalier de la létion d'honneur” in 2016, and received awards from the French Science Academy (2017) and the Rynd Award from the Irish Society of Anesthesiologists (2022).Dr. Didier Bouhassira (MD, PhD) has been trained in neurology and neurophysiology in Paris. He has been involved in both basic and clinical research on pain and is currently Director of Research at the National Institut for Health and Medical Research (Inserm). He is associate attending neurologist in the Pain Clinic at Ambroise Paré hospital in Boulogne-Billancourt and director of the laboratory of "Pathophysiology and Clinical Pharmacology of Pain" (Inserm U-987). Didier Bouhassira was president of the French Pain Society (2013-2016) and is an active member of several international associations or societies. He has been field editor for the European Journal of Pain (2008-2021) and associate editor for several scientific journals including Pain. He has co-authored over 220 articles in peer reviewed journals and has written a number of book chapters devoted to the pharmacology and pathophysiology of pain.

This is an excellent handbook regarding management of neuropathic pain for a variety of providers written in accessible language and digestible format. The succinct chapters make it easy to learn something new with short periods of time, and for using the resources included as references for specific clinical questions.

• SECTION I: CLINICAL CASES, DIAGNOSIS AND MANAGEMENT 1. Is this neuropathic pain? 2. How do I implement therapeutic management? 3. Back and leg pain 4. Paresthesia of the hand 5. Itch and herpes zoster 6. Painful legs and diabetes, case 1 7. Painful legs and diabetes, case 2 8. Groin pain after hernia repair 9. Pain after surgery for hand fracture 10. Pain and amputation 11. Pain and breast cancer surgery 12. Cold evoked symptoms after chemotherapy 13. Cervicobrachial pain and cancer 14. My body is boiling 15. Pain and Covid 19 16. Pelvic pain 17. Burning mouth 18. Orofacial pain 19. A lightning in the face 20. Brachial plexus avulsion 21. Pain and paraplegia l 22. Pain and multiple sclerosis 23. Sudden onset facial pain 24. Pain and Parkinson 25. Burning hands 26. Neuropathic pain in a child SECTION II: THERAPEUTIC OPTIONS IN PRIMARY CARE 27. Antidepressants and antiepileptics 28. Topical therapy 29. The case of opioids 30. Physical therapy 31. Psychotherapies 32. Complementary medicine 33. Transcutaneous electrical nerve stimulation SECTION III: SPECIALIZED ASSESSMENT AND THERAPY 34. Management of high risk patients 35. Management of patients with comorbididies 36. Management of neuropathic pain: role of patient reported outcome measures 37. Management of neuropathic pain: role of quantitative sensory testing 38. Complementary investigations 39. The case of cannabinoids 40. Nerve blocks and drug infusions 41. Noninvasive brain stimulation 42. When do I refer for invasive therapies? 43. Peripheral nerve stimulation and radiofrequency 44. Spinal cord stimulation 45. Invasive brain stimulation and intrathecal therapy

Nadine Attal, MD, PhD, is a neurologist, Professor of Therapeutics and Pain Medicine at Paris Saclay University, head of The Pain Center at Hôpital Ambroise Paré, Boulogne-Billancourt, France and associate director of the U 987 INSERM research Unit. She has played a leading role in translational research in pain and has published in leading journals. She is section editor for BJA and PainReports and Councilmember of the International Association for the Study of Pain. She was appointed “chevalier de la létion d'honneur” in 2016, and received awards from the French Science Academy (2017) and the Rynd Award from the Irish Society of Anesthesiologists (2022).Dr. Didier Bouhassira (MD, PhD) has been trained in neurology and neurophysiology in Paris. He has been involved in both basic and clinical research on pain and is currently Director of Research at the National Institut for Health and Medical Research (Inserm). He is associate attending neurologist in the Pain Clinic at Ambroise Paré hospital in Boulogne-Billancourt and director of the laboratory of "Pathophysiology and Clinical Pharmacology of Pain" (Inserm U-987). Didier Bouhassira was president of the French Pain Society (2013-2016) and is an active member of several international associations or societies. He has been field editor for the European Journal of Pain (2008-2021) and associate editor for several scientific journals including Pain. He has co-authored over 220 articles in peer reviewed journals and has written a number of book chapters devoted to the pharmacology and pathophysiology of pain.

This is an excellent handbook regarding management of neuropathic pain for a variety of providers written in accessible language and digestible format. The succinct chapters make it easy to learn something new with short periods of time, and for using the resources included as references for specific clinical questions.

• SECTION I: CLINICAL CASES, DIAGNOSIS AND MANAGEMENT 1. Is this neuropathic pain? 2. How do I implement therapeutic management? 3. Back and leg pain 4. Paresthesia of the hand 5. Itch and herpes zoster 6. Painful legs and diabetes, case 1 7. Painful legs and diabetes, case 2 8. Groin pain after hernia repair 9. Pain after surgery for hand fracture 10. Pain and amputation 11. Pain and breast cancer surgery 12. Cold evoked symptoms after chemotherapy 13. Cervicobrachial pain and cancer 14. My body is boiling 15. Pain and Covid 19 16. Pelvic pain 17. Burning mouth 18. Orofacial pain 19. A lightning in the face 20. Brachial plexus avulsion 21. Pain and paraplegia l 22. Pain and multiple sclerosis 23. Sudden onset facial pain 24. Pain and Parkinson 25. Burning hands 26. Neuropathic pain in a child SECTION II: THERAPEUTIC OPTIONS IN PRIMARY CARE 27. Antidepressants and antiepileptics 28. Topical therapy 29. The case of opioids 30. Physical therapy 31. Psychotherapies 32. Complementary medicine 33. Transcutaneous electrical nerve stimulation SECTION III: SPECIALIZED ASSESSMENT AND THERAPY 34. Management of high risk patients 35. Management of patients with comorbididies 36. Management of neuropathic pain: role of patient reported outcome measures 37. Management of neuropathic pain: role of quantitative sensory testing 38. Complementary investigations 39. The case of cannabinoids 40. Nerve blocks and drug infusions 41. Noninvasive brain stimulation 42. When do I refer for invasive therapies? 43. Peripheral nerve stimulation and radiofrequency 44. Spinal cord stimulation 45. Invasive brain stimulation and intrathecal therapy

Nadine Attal, MD, PhD, is a neurologist, Professor of Therapeutics and Pain Medicine at Paris Saclay University, head of The Pain Center at Hôpital Ambroise Paré, Boulogne-Billancourt, France and associate director of the U 987 INSERM research Unit. She has played a leading role in translational research in pain and has published in leading journals. She is section editor for BJA and PainReports and Councilmember of the International Association for the Study of Pain. She was appointed “chevalier de la létion d'honneur” in 2016, and received awards from the French Science Academy (2017) and the Rynd Award from the Irish Society of Anesthesiologists (2022).Dr. Didier Bouhassira (MD, PhD) has been trained in neurology and neurophysiology in Paris. He has been involved in both basic and clinical research on pain and is currently Director of Research at the National Institut for Health and Medical Research (Inserm). He is associate attending neurologist in the Pain Clinic at Ambroise Paré hospital in Boulogne-Billancourt and director of the laboratory of "Pathophysiology and Clinical Pharmacology of Pain" (Inserm U-987). Didier Bouhassira was president of the French Pain Society (2013-2016) and is an active member of several international associations or societies. He has been field editor for the European Journal of Pain (2008-2021) and associate editor for several scientific journals including Pain. He has co-authored over 220 articles in peer reviewed journals and has written a number of book chapters devoted to the pharmacology and pathophysiology of pain.

This is an excellent handbook regarding management of neuropathic pain for a variety of providers written in accessible language and digestible format. The succinct chapters make it easy to learn something new with short periods of time, and for using the resources included as references for specific clinical questions.

• SECTION I: CLINICAL CASES, DIAGNOSIS AND MANAGEMENT 1. Is this neuropathic pain? 2. How do I implement therapeutic management? 3. Back and leg pain 4. Paresthesia of the hand 5. Itch and herpes zoster 6. Painful legs and diabetes, case 1 7. Painful legs and diabetes, case 2 8. Groin pain after hernia repair 9. Pain after surgery for hand fracture 10. Pain and amputation 11. Pain and breast cancer surgery 12. Cold evoked symptoms after chemotherapy 13. Cervicobrachial pain and cancer 14. My body is boiling 15. Pain and Covid 19 16. Pelvic pain 17. Burning mouth 18. Orofacial pain 19. A lightning in the face 20. Brachial plexus avulsion 21. Pain and paraplegia l 22. Pain and multiple sclerosis 23. Sudden onset facial pain 24. Pain and Parkinson 25. Burning hands 26. Neuropathic pain in a child SECTION II: THERAPEUTIC OPTIONS IN PRIMARY CARE 27. Antidepressants and antiepileptics 28. Topical therapy 29. The case of opioids 30. Physical therapy 31. Psychotherapies 32. Complementary medicine 33. Transcutaneous electrical nerve stimulation SECTION III: SPECIALIZED ASSESSMENT AND THERAPY 34. Management of high risk patients 35. Management of patients with comorbididies 36. Management of neuropathic pain: role of patient reported outcome measures 37. Management of neuropathic pain: role of quantitative sensory testing 38. Complementary investigations 39. The case of cannabinoids 40. Nerve blocks and drug infusions 41. Noninvasive brain stimulation 42. When do I refer for invasive therapies? 43. Peripheral nerve stimulation and radiofrequency 44. Spinal cord stimulation 45. Invasive brain stimulation and intrathecal therapy