Reed E. Pyeritz is the William Smilow Professor of Medicine and Genetics, Emeritus, at the Perelman School of Medicine, University of Pennsylvania. He received his B.S. from the University of Delaware, a Ph.D. in biological chemistry from Harvard University, and an M.D. from Harvard Medical School. His clinical practice focuses on adults with hereditary disorders, especially of the cardiovascular system. His research contributed to the lifespan of people with Marfan syndrome improving from the mid-forties to the seventies. Long interested in medical economics and ethics, he has studied the professional obligations of providers of genetics services and the financial influences that limit access. He has published over 700 research studies, reviews, and chapters, and co-edits Principles and Practice of Medical Genetics and Genomics.

• 1. Introduction2. Personalized Medicine Cannot Always be Precise, But Precision Medicine Must Always Be Personalized3. Uncertainty as a Fact of Life4. Uncertainty Pervades All Healthcare 5. Artificial Intelligence: Origins, Applications and Challenges6. How Artificial Intelligence Enhances Healthcare7. Our -Omics8. Our Genomes9. Exploring Our Genes10. Faster, Higher, Stronger: Uncertainties in Athletics11. Is Ageing a Terminal Disease?12. Future Casting13. Departing Thoughts

Reed E. Pyeritz is the William Smilow Professor of Medicine and Genetics, Emeritus, at the Perelman School of Medicine, University of Pennsylvania. He received his B.S. from the University of Delaware, a Ph.D. in biological chemistry from Harvard University, and an M.D. from Harvard Medical School. His clinical practice focuses on adults with hereditary disorders, especially of the cardiovascular system. His research contributed to the lifespan of people with Marfan syndrome improving from the mid-forties to the seventies. Long interested in medical economics and ethics, he has studied the professional obligations of providers of genetics services and the financial influences that limit access. He has published over 700 research studies, reviews, and chapters, and co-edits Principles and Practice of Medical Genetics and Genomics.

• 1. Introduction2. Personalized Medicine Cannot Always be Precise, But Precision Medicine Must Always Be Personalized3. Uncertainty as a Fact of Life4. Uncertainty Pervades All Healthcare 5. Artificial Intelligence: Origins, Applications and Challenges6. How Artificial Intelligence Enhances Healthcare7. Our -Omics8. Our Genomes9. Exploring Our Genes10. Faster, Higher, Stronger: Uncertainties in Athletics11. Is Ageing a Terminal Disease?12. Future Casting13. Departing Thoughts

Reed E. Pyeritz is the William Smilow Professor of Medicine and Genetics, Emeritus, at the Perelman School of Medicine, University of Pennsylvania. He received his B.S. from the University of Delaware, a Ph.D. in biological chemistry from Harvard University, and an M.D. from Harvard Medical School. His clinical practice focuses on adults with hereditary disorders, especially of the cardiovascular system. His research contributed to the lifespan of people with Marfan syndrome improving from the mid-forties to the seventies. Long interested in medical economics and ethics, he has studied the professional obligations of providers of genetics services and the financial influences that limit access. He has published over 700 research studies, reviews, and chapters, and co-edits Principles and Practice of Medical Genetics and Genomics.

• 1. Introduction2. Personalized Medicine Cannot Always be Precise, But Precision Medicine Must Always Be Personalized3. Uncertainty as a Fact of Life4. Uncertainty Pervades All Healthcare 5. Artificial Intelligence: Origins, Applications and Challenges6. How Artificial Intelligence Enhances Healthcare7. Our -Omics8. Our Genomes9. Exploring Our Genes10. Faster, Higher, Stronger: Uncertainties in Athletics11. Is Ageing a Terminal Disease?12. Future Casting13. Departing Thoughts