The Oxford Handbook of Clinical Immunology and Allergy is a practical and clinically based guide primarily aimed at trainees, doctors, nurses, and laboratory staff working in immunology and general physicians who require a succinct review of current immunological and allergic disease. It serves as an invaluable aid to diagnosis and management, providing examples of the correct selection and interpretation of immunological tests for a wide range of conditions. The handbook also works as a succinct revision guide for the FRCPath in Immunology. Split into two sections, the first covers individual diseases and allergies, including diagnostic and management strategies, while the second describes appropriate laboratory tests and their interpretation. The fifth edition has been extensively revised and updated to feature the latest advances in the field. There has been an exponential increase in the number of Inborn Errors of Immunity (IEI) and the chapter on immunodeficiencies has been updated and reorganised to reflect this and map to the IUIS classification. Likewise, the application of genetic engineering techniques has led to an increase in the production of therapeutic monoclonal antibodies. A range of new small molecule inhibitors of specific activation pathways in the immune system is revolutionising therapy of immunological diseases and malignancy but brings the risks of secondary immunodeficiency. Molecular diagnosis for all types of immunological disease is now available, and this has given new insights into diseases and sometimes into basic immunological pathways and mechanisms. This essential companion equips readers with up-to-date guidance rooted in current clinical immunology
