Organic Chemistry

Jonathan Clayden is a Professor of Organic Chemistry at the University of Manchester, where he and his research group work on the construction of molecules with defined shapes - in particular those where control of conformation and limitation of flexibility is important. Jonathan was awarded a BA (Natural Sciences) from Churchill College, Cambridge before completing his PhD with Stuart Warren, also at the University of Cambridge. He has been at the University of Manchester since 1994.Nick Greeves is the Director of Teaching and Learning in the Department of Chemistry at the University of Liverpool. Nick is a Cambridge graduate, obtaining his PhD there in 1986 for work on the stereoselective Horner-Wittig reaction with Stuart Warren. He then held a Harkness Fellowship at the University of Wisconsin-Madison and at Stanford University, California, and a Research Fellowship at Cambridge University before joining Liverpool in 1989 where he is currently a Senior Lecturer.Stuart Warren is a former lecturer in the Department of Chemistry at the University of Cambridge and Fellow of Churchill College, Cambridge. A graduate of Trinity College, Cambridge, Stuart completed his PhD at Cambridge with Malcolm Clark before carrying out post-doctoral research at Harvard University. He became a teaching fellow at Churchill College in 1971, and remained a lecturer and researcher at Cambridge until his retirement in 2006.

It is a credit to the authors that a textbook that I have adored for so many years has undergone such a substantial overhaul and yet still retains the features that made it quite so attractive to students in the first place. This is a book that will continue to inspire students of organic chemistry for many years to come. Even if you already have the first edition, I am happy to recommend that you invest in this new version you will not be disappointed.

• 1. What is organic chemistry? ; 2. Organic structures ; 3. Determining organic structures ; 4. Structure of molecules ; 5. Organic reactions ; 6. Nucleophilic addition to the carbonyl group ; 7. Delocalization and conjugation ; 8. Acidity, basicity, and pKa ; 9. Using organometallic reagents to make C-C bonds ; 10. Nucleophilic substitution at the carbonyl group ; 11. Nucleophilic substitution at C=O with loss of carbonyl oxygen ; 12. Equilibria, rates and mechanisms ; 13. 1H NMR: Proton nuclear magnetic resonance ; 14. Stereochemistry ; 15. Nucleophilic substitution at saturated carbon ; 16. Conformational analysis ; 17. Elimination reactions ; 18. Review of spectroscopic methods ; 19. Electrophilic addition to alkenes ; 20. Formation and reactions of enols and enolates ; 21. Electrophilic aromatic substitution ; 22. Conjugate addition and nucleophilic aromatic substitution ; 23. Chemoselectivity and protecting groups ; 24. Regioselectivity ; 25. Alkylation of enolates ; 26. Reactions of enolates with carbonyl compounds: the aldol and Claisen reactions ; 27. Sulfur, silicon and phosphorus in organic chemistry ; 28. Retrosynthetic analysis ; 29. Aromatic heterocycles 1: structures and reactions ; 30. Aromatic heterocycles 2: synthesis ; 31. Saturated heterocycles and stereoelectronics ; 32. Stereoselectivity in cyclic molecules ; 33. Diastereoselectivity ; 34. Pericyclic reactions 1: cycloadditions ; 35. Pericyclic reactions 2: sigmatropic and electrocyclic reactions ; 36. Participation, rearrangement and fragmentation ; 37. Radical reactions ; 38. Synthesis and reactions of carbenes ; 39. Determining reaction mechanisms ; 40. Organometallic chemistry ; 41. Asymmetric synthesis ; 42. Organic chemistry of life ; 43. Organic chemistry today