Jonathan Clayden – författare

This volume, number 23 in the "Tetrahedron Organic Chemistry" series, presents organolithium chemistry from the perspective of a synthetic organic chemist, drawing from the synthetic literature to present a unified overview of how organolithiums can be used to make molecules. The development of methods for the regioselective synthesis of organolithiums has replaced their image of indiscriminate high reactivity with one of controllable and subtle selectivity. Organolithium chemistry has a central role in the selective construction of C-C bonds in both simple and complex molecules, and for example has arguably overtaken aromatic electrophilic substitution as the most powerful method for regioselective functionalisation of aromatic rings. The twin themes of reactivity and selectivity run through the book, which reviews the ways by which organolithiums may be formed and the ways in which they react. Topics include advances in directed metallation, reductive lithiation and organolithium cyclisation reactions, along with a discussion of organolithium stereochemistry and the role played by ligands such as (-)-sparteine.

Inspiring and motivating students from the moment it published, Organic Chemistry has established itself in just one edition as the students' choice of organic chemistry text. This second edition takes all that has made Organic Chemistry the book of choice, and has refined and refocused it to produce a text that is even more student-friendly, more coherent and more logical in its presentation than before.At heart, the second edition remains true to the first, being built on three principles:An explanatory approach, through which the reader is motivated to understand the subject and not just learn the facts;A mechanistic approach, giving the reader the power to understand compounds and reactions never previously encountered;An evidence-based approach, setting out clearly how and why reactions happen as they do, giving extra depth to the reader's understanding.The authors write clearly and directly, sharing with the reader their own fascination with the subject, and leading them carefully from topic to topic. Their honest and open narrative flags pitfalls and misconceptions, guiding the reader towards a complete picture of organic chemistry and its universal themes and principles.Enriched with an extensive bank of online resources to help the reader visualise the structure of organic compounds and their reaction mechanisms, this second edition reaffirms the position of Organic Chemistry as the essential course companion for all organic chemistry students. Online Resource CentreFor students:A range of problems to accompany each chapterFor registered adopters of the text:Figures from the book in electronic format

The solutions manual to accompany Organic Chemistry provides fully-explained solutions to all the problems that feature in the second edition of Organic Chemistry . Intended for students and instructors alike, the manual provides helpful comments and friendly advice to aid understanding, and is an invaluable resource wherever Organic Chemistry is used for teaching and learning.