Paraneoplastic Syndromes

Dr. Darnell studied neurology as Chief Resident with Dr. Fred Plum at The New York Hospital, Cornell, and then, beginning in 1990 and continuing through the present time, with Dr. Jerome Posner at Memorial Sloan-Kettering Cancer Center. Dr. Darnell is currently the Heilbrunn Cancer Professor and Senior Physician at The Rockefeller University and an Investigator with the Howard Hughes Medical Institute, and is an Affiliate Attending Neurologist at Memorial Sloan-Kettering Cancer Center. Dr. Posner did a Neurology residency at the University of Washington under Dr. Fred Plum. C. Cotzias of Neuro-Oncology at Memorial Sloan-Kettering cancer Center and was recently in only clinical research professor ship from the American Cancer Society.

"In a field such as paraneoplastic syndromes that is changing constantly, Drs Posner and Darnell have written a book to stay. Divided in 17 chapters covering historical aspects, individual syndromes, type of immune responses, and specific cancers the authors describe in a detail only possible from physicians with extensive experience, all paraneoplastic neurological and non-neurological syndromes known to date. There are abundant and excellent vignettes,tables, and pictures. Given that any part of the nervous system and any organ may be affected by these disorders, this is a book that any physician should read and keep on the bookshelf." --Josep Dalmau,MD, PhD, ICREA Research Professor, IDIBAPS/Hospital Clinic, University of Barcelona, Spain, and adjunct Professor of Neurology, University of Pennsylvania, Philadelphia, PA"Paraneoplastic Syndromes is another wonderful volume in the distinguished Contemporary Neurology Series by Robert Darnell and Jerry Posner...This book may be read as a single unit, or it may be used as a complete resource for selective referencing. The illustrations and figures are of high quality and descriptive. This book will be useful for students, residents, and the experienced practitioner who is looking for a definitive book onthis topic. It is written to help the clinician with understanding the pathophysiology and diagnosis of this baffling disease syndrome. Moreover, basic scientists and neuroanatomists will appreciate the care that hasbeen placed into the analysis of the anatomical pathophysiology of this disease." -- Thomas Chen, MD, PhD, Director, USC Neuro-oncology, Departments of Neurosurgery and Pathology, Los Angeles, CA"Dr. Posner and Dr. Darnell's Paraneoplastic Syndromes is a comprehensive and accessible review by two of the world's experts of an area of medicine that bridges the fields of neurology, oncology, and immunology. Despite the potential complexity of these disorders, the thoughtful organization and clarity of presentation of this volume, with sections organized by specific clinical syndromes, antibodies, and cancer types, makes this an essentialreference both clinicians and scientists with an interest in paraneoplastic syndromes." --Howard Colman, MD, PhD, Director of Medical Neuro-Oncology, Department of Neurosurgery and Huntsman Cancer Institute, Universityof Utah School of Medicine, Salt Lake City, UT

• Contents ; SECTION 1 OVERVIEW ; 1. HISTORY ; DEFINITIONS ; CLASSIFICATION ; HISTORY ; Pathogenesis ; EPIDEMIOLOGY ; IMPORTANCE ; 2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS ; INTRODUCTION ; CLINICAL APPROACH ; The Patient without Known Cancer The Patient with Known Cancer ; CLUES TO DIAGNOSIS ; Clinical Findings Laboratory Investigation ; PATHOLOGY ; TREATMENT ; Plasma Exchange (Plasmapheresis) Intravenous Immunoglobulin ; Rituximab Cyclophosphamide Corticosteroids Human Chorionic Gonadotropin Recommendations ; PROGNOSIS ; 3. PATHOGENESIS ; INTRODUCTION ; HISTORICAL VIEWS ; Toxic Substances Competition for Essential Substrate Bullet Opportunistic Infection Immune Mediated ; CURRENT CONCEPTS OF PATHOGENESIS ; Unresolved Questions Conclusions ; ANIMAL MODELS ; SECTION 2 CLINICAL SYNDROMES ; 4. BRAIN (CEREBRUM) ; INTRODUCTION ; CEREBRAL CORTEX ; WHITE MATTER DEMYELINATION ; BLOOD VESSELS (VASCULITIS) ; HIPPOCAMPUS/LYMBIC ENCEPHALITIS ; TASTE