'This book is a valuable addition to the literature.' Quarterly Review of Biology, March 1998

• I. Cell Cycle and Signaling Pathways in Apoptosis.- 1. Apoptosis/Programmed Cell Death: A Historical Perspective.- 2. Apoptosis and Its Regulation.- 3. Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages.- 4. Cytotoxic Lymphocyte Killing Enters the ICE Age.- 5. Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231.- 6. Cell Cycle Control of T Cell Apoptosis Induced by Activation through the T Cell Antigen Receptor.- 7. Role of Antibody Signaling in Inducing Tumor Dormancy.- II. Apoptosis-Regulating Genes.- 8. Regulation of Lymphoid Apoptosis by Bcl-2 and Bcl-xL.- 9. The Epstein—Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene Bcl-2, Inhibits Apoptosis Induced by Gamma Radiation and Chemotherapeutic Drugs.- 10. Structure—Function Analysis of Bcl-2 Family Proteins: Regulators of Programmed Cell Death.- 11. Role of ICE-Proteases in Apoptosis.- 12. Fas-Mediated Apoptosis.- 13. Fas Splicing Variants and Their Effect on Apoptosis.- 14. The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses.- III. Apoptosis in B Cells.- 15. Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes.- 16. Regulation of B Cell Apoptosis.- 17. Apoptotic Cell Death in the Chicken Bursa of Fabricius.- 18. Generation and Regulation of B Cell Autoreactivity Arising in the Periphery.- 19. Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes.- IV Apoptosis in T Cells.- 20. The Thymus and T Cell Death.- 21. Genetic Regulation of Apoptosis in the Mouse Thymus.- 22. Regulation of T Cell Activation by CD28 and CTLA4.- 23. Granzyme B-Induced Apoptosis.- 24. Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System.- 25. Autoimmunity Due to Defective NUR77, Fas,and TNF-RI Apoptosis.

'This book is a valuable addition to the literature.' Quarterly Review of Biology, March 1998

• I. Cell Cycle and Signaling Pathways in Apoptosis.- 1. Apoptosis/Programmed Cell Death: A Historical Perspective.- 2. Apoptosis and Its Regulation.- 3. Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages.- 4. Cytotoxic Lymphocyte Killing Enters the ICE Age.- 5. Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231.- 6. Cell Cycle Control of T Cell Apoptosis Induced by Activation through the T Cell Antigen Receptor.- 7. Role of Antibody Signaling in Inducing Tumor Dormancy.- II. Apoptosis-Regulating Genes.- 8. Regulation of Lymphoid Apoptosis by Bcl-2 and Bcl-xL.- 9. The Epstein—Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene Bcl-2, Inhibits Apoptosis Induced by Gamma Radiation and Chemotherapeutic Drugs.- 10. Structure—Function Analysis of Bcl-2 Family Proteins: Regulators of Programmed Cell Death.- 11. Role of ICE-Proteases in Apoptosis.- 12. Fas-Mediated Apoptosis.- 13. Fas Splicing Variants and Their Effect on Apoptosis.- 14. The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses.- III. Apoptosis in B Cells.- 15. Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes.- 16. Regulation of B Cell Apoptosis.- 17. Apoptotic Cell Death in the Chicken Bursa of Fabricius.- 18. Generation and Regulation of B Cell Autoreactivity Arising in the Periphery.- 19. Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes.- IV Apoptosis in T Cells.- 20. The Thymus and T Cell Death.- 21. Genetic Regulation of Apoptosis in the Mouse Thymus.- 22. Regulation of T Cell Activation by CD28 and CTLA4.- 23. Granzyme B-Induced Apoptosis.- 24. Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System.- 25. Autoimmunity Due to Defective NUR77, Fas,and TNF-RI Apoptosis.

'This book is a valuable addition to the literature.' Quarterly Review of Biology, March 1998

• I. Cell Cycle and Signaling Pathways in Apoptosis.- 1. Apoptosis/Programmed Cell Death: A Historical Perspective.- 2. Apoptosis and Its Regulation.- 3. Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages.- 4. Cytotoxic Lymphocyte Killing Enters the ICE Age.- 5. Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231.- 6. Cell Cycle Control of T Cell Apoptosis Induced by Activation through the T Cell Antigen Receptor.- 7. Role of Antibody Signaling in Inducing Tumor Dormancy.- II. Apoptosis-Regulating Genes.- 8. Regulation of Lymphoid Apoptosis by Bcl-2 and Bcl-xL.- 9. The Epstein—Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene Bcl-2, Inhibits Apoptosis Induced by Gamma Radiation and Chemotherapeutic Drugs.- 10. Structure—Function Analysis of Bcl-2 Family Proteins: Regulators of Programmed Cell Death.- 11. Role of ICE-Proteases in Apoptosis.- 12. Fas-Mediated Apoptosis.- 13. Fas Splicing Variants and Their Effect on Apoptosis.- 14. The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses.- III. Apoptosis in B Cells.- 15. Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes.- 16. Regulation of B Cell Apoptosis.- 17. Apoptotic Cell Death in the Chicken Bursa of Fabricius.- 18. Generation and Regulation of B Cell Autoreactivity Arising in the Periphery.- 19. Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes.- IV Apoptosis in T Cells.- 20. The Thymus and T Cell Death.- 21. Genetic Regulation of Apoptosis in the Mouse Thymus.- 22. Regulation of T Cell Activation by CD28 and CTLA4.- 23. Granzyme B-Induced Apoptosis.- 24. Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System.- 25. Autoimmunity Due to Defective NUR77, Fas,and TNF-RI Apoptosis.