Therapeutic Enzymes: Function and Clinical Implications

Häftad, Engelska, 2020

Del 1148 i serien Advances in Experimental Medicine and Biology

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Beskrivning

Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes.

Produktinformation

Utgivningsdatum:2020-09-23
Mått:178 x 254 x 20 mm
Vikt:832 g
Format:Häftad
Språk:Engelska
Serie:Advances in Experimental Medicine and Biology
Antal sidor:386
Förlag:Springer Verlag, Singapore
ISBN:9789811377112

Utforska kategorier

Innehållsförteckning

Chapter 1. Introduction to therapeutic enzymes.- Chapter 2. Upstream processing technologies.- Chapter 3. Downstream processing technologies.- Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations.- Chapter 5. Regulatory guidance in the production of therapeutic enzymes.- Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics Bertrand Raynal Patrick England.- Chapter 7. Clinical Development of a therapeutic enzyme.- Chapter 8. Chemical modifications of therapeutic proteins.- Chapter 9. Formulation of therapeutic enzymes.- Chapter 10. Engineering of therapeutic enzymes for improving activity.- Chapter 11. Engineering of therapeutic enzymes for improving stability.- Chapter 12. Design and engineering of deimmunized therapeutic enzymes.- Chapter 13. Nanoparticles for delivery of therapeutic enzymes.- Chapter 14. Targeted delivery of therapeutic enzymes.- Chapter 15. Oral and inhalable enzyme therapies.- Chapter 16. Regulatory issues.- Chapter 17. Enzyme replacement therapies.- Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy.- Chapter 19. Enzyme therapy for lysosomal storage disorders.- Chapter 20. Enzyme therapy for myocardial infarction.- Chapter 21. Enzyme therapy for chronic gout.- Chapter 22. Enzyme therapy for tumor lysis syndrome.- Chapter 23. Enzyme therapy for collagen-based disorders.- Chapter 24. Enzyme therapy for severe combined immunodeficiency disease.- Chapter 25. Enzyme therapy for detoxification of methotrexate.- Chapter 26. Enzyme therapy vitreomacular adhesion.- Chapter 27. L-Asparaginase as anticancer agent.- Chapter 28. Pancreatic enzyme replacement therapy.- Chapter 29. Enzymes in metabolic anticancer therapy.- Chapter 30. L-Arginase for L-Arg depletion therapy incancer.- Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer.- Chapter 32. Enzyme therapy for celiac sprue.- Chapter 33. Acid ceramidase.- Chapter 34. Lysosomal acid lipase.- Chapter 35. Alkaline phosphatase and hypophosphatasia.- Chapter 36. Enzybiotics: Antibiotic enzymes as drugs and therapeutics.- Chapter 37. Anti-inflammatory enzymes.- Chapter 38. Phenylalanine ammonia lyase for the treatment of phenylketonuria.- Chapter 39. Clinical applications of Hyaluronidase.- Chapter 40. Superoxide dismutase and oxidative stress modulation.- Chapter 41. Organophosphate hydrolases as catalytic bioscavengers.- Chapter 42. Novel therapeutic proteases.- Chapter 43. Genome-editing enzymes.- Chapter 44. Gene therapy for enzyme deficiency: current status and future prospects.