Cancer Gene Therapy

Past Achievements and Future Challenges

AvNagy Habib

Inbunden, Engelska, 2000

Del i serien Advances in Experimental Medicine and Biology

2 239 kr

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Beskrivning

Bringing together major work achieved during the 1990s in the field of cancer gene therapy, this text focuses on the achievements and definition of future goals. Providing a picture of the vectors available to carry genes in human tumours, it describes the available genes with different mechanisms of action as well as different systems that could be used for targeting tumour cells in humans.

Produktinformation

Utgivningsdatum:2000-04-30
Mått:156 x 234 x undefined mm
Format:Inbunden
Språk:Engelska
Serie:Advances in Experimental Medicine and Biology
Antal sidor:496
Förlag:Springer Science+Business Media
ISBN:9780306461910

Utforska kategorier

Onkologi inom Medicin

Innehållsförteckning

The Clinical Problem.- Management Problems in Oncology.- Vectors.- Adenoviral Vectors.- Retrovirus Vectors.- Targetable Gene Delivery Vectors.- Human ?-fetoprotein Transcriptional Regulatory Sequences.- Tumor-Targeted Salmonella.- Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells.- Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy.- Cochleates.- The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer.- Cell Cycle Control.- Adhesion Molecules in Cancer Biology.- Cell Cycle Control.- Apoptosis.- Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death.- Apoptin®.- Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors.- Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer.- Tumout Suppressor Genes.- Pre-clinical Studies with Tumor Suppressor Genes.- Gene Therapy for Liver Tumours.- Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer.- Other Systems.- Eliciting Hyperacute Rejection as a Tumor Killing Strategy.- Innate Immune Therapy For Cancer.- Mda-7, A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy.- Antisense and Ribozymes.- Antisense IGF and Antisense IGF-IR Therapy of Malignancy.- Sensitization of Tumors to Chemotherapy Through Gene Therapy.- Design and Testing of Ribozymes for Cancer Gene Therapy.- Ribozymes.- The Approach of Triple Helix Formation in Control of Gene Expression and The Treatment of Tumors Expressing IGF-I.- Immuno-Modulation.- Dendritic Cell-based Immunization for Cancer Therapy.- Hybrid Cell Vaccination for Cancer Immunotherapy.- Modulation of the Immune Response Through 4-1BB.- Heat Shock Proteinsin Cancer Therapy.- Bi-Specific Antibodies in Cancer Therapy.- B7.1 and Cytokines.- Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma.- Suicidal Genes.- Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT).- Suicide Gene Therapy.- Adenoviruses as Gene Delivery Vectors.- Angiogenesis Control.- Evaluation of an Inhibitor of DNA Methylation, 5-aza-2?-Deoxycytidine, for The Treatment of Lung Cancer and the Future Role of Gene Therapy.- Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy.- Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy.- Matrix Metallo Proteinase.- Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression For Cancer Gene Therapy.