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• Front MatterSummarySummary Annex Report Conclusions by Level of Evidence1 Introduction2 Committee ApproachSection I: E-Cigarette Devices, Constituents, and Exposures3 E-Cigarette Devices, Uses, and Exposures4 Nicotine5 Toxicology of E-Cigarette Constituents6 Research Needs: E-Cigarette Devices, Constituents, and ExposuresSection II: Effects of E-Cigarettes on Health7 Modes of Action8 Dependence and Abuse Liability9 Cardiovascular Disease10 Cancers11 Respiratory Diseases12 Oral Diseases13 Developmental and Reproductive Effects14 Injuries and Poisonings15 Research Needs: Effects of E-Cigarettes on HealthSection III: Public Health Implications of E-Cigarettes16 Combustible Tobacco Cigarette Smoking Among Youth and Young Adults17 Smoking Cessation Among Adults18 Harm Reduction19 Modeling of E-Cigarette Use20 Research Needs: Public Health Implications of E-Cigarettes21 Concluding ObservationsAppendix A: Questions from the Center for Tobacco Products of the Food and Drug Administration Submitted for the Committee's ConsiderationAppendix B: Search Strategy and Quality AssessmentAppendix C: Glossary of Terms Related to E-CigarettesAppendix D: Cytotoxicity TablesAppendix E: Public Meeting AgendaAppendix F: Committee Biosketches