Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022). Arthur L. Day, MD, is a board-certified and fellowship-trained neurosurgeon with specific cerebrovascular and skull-base neurosurgery expertise. He specializes in the microsurgical treatment of brain tumors and minimally invasive spinal surgery. Dr. Day is also a professor in the Vivian L. Smith Department of Neurosurgery at McGovern Medical School at UTHealth Houston.

"The book covers the basic gross anatomy with histopathology and etiopathogenesis of different types of strokes. The best aspect is the very well organized elaboration of disease characteristics with pathophysiological changes through to treatment." --© Doody’s Review Service,2021,Ram K Saha, M.D. (Thomas Jefferson University) Score: 92-4 Stars!

• Section 1 Pathophysiology1. Cerebral Vascular Biology in Health and Disease2. Mechanisms of Thrombosis and Thrombolysis3. Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease4. Histopathology of Brain Tissue Response to Stroke and Injury5. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death6. Intracellular Signaling: Mediators and Protective Responses7. The Neurovascular Unit and Responses to Ischemia8. Mechanisms of Damage After Cerebral Hemorrhage9. White Matter Pathophysiology10. Cerebral Ischemia and Inflammation11. Mechanisms of Plasticity, Remodeling and Recovery12. Genetics and Vascular Biology of Brain Vascular Malformations13. Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and DementiaSection 2 Epidemiology and Risk Factors14. Global Burden of Stroke15. Stroke Disparities16. Risk Factors and Prevention17. Prognosis after Stroke18. Vascular Dementia and Cognitive Impairment19. Genetic Basis of Stroke Occurrence, Prevention and OutcomeSection 3 Clinical Manifestations20. Classification of Ischemic Stroke21. Clinical Scales to Assess Patients with Stroke22. Carotid Artery Disease23. Anterior Cerebral Artery Disease24. Middle Cerebral Artery Disease25. Posterior Cerebral Artery Disease26. Vertebrobasilar Disease27. Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease28. Intracerebral Hemorrhage29. Aneurysmal Subarachnoid Hemorrhage30. Arteriovenous Malformations and Other Vascular Anomalies31. Stroke and Other Vascular Syndromes of the Spinal CordSection 4 Specific Conditions and Stroke32. Cardiac Diseases33. Atherosclerotic Disease of the Proximal Aorta34. Stroke Related to Surgery and Other Procedures35. Arterial Dissection, Fibromuscular Dysplasia, and Carotid Web36. Inflammatory and Infectious Vasculopathies37. Reversible Cerebral Vasoconstriction Syndromes38. Posterior Reversible Encephalopathy Syndrome39. Stroke and Substance Abuse40. Moyamoya Disease41. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy42. Hematologic Disorders and Stroke43. Migraine and Stroke44. Cryptogenic Stroke45. Cerebral Venous ThrombosisSection 5 Diagnostic Studies46. Ultrasonography47. Computed Tomography-Based Evaluation of Cerebrovascular Disease48. Magnetic Resonance Imaging of Cerebrovascular Diseases49. Cerebral Angiography50. OMICs in Stroke: Insight into stroke through epigenomics, transcriptomics, proteomics, lipidomics, and metabolomicsSection 6 TherapyPart A: Medical Therapy51. Stroke Systems of Care and Impact on Acute Stroke Treatment52. Prehospital and Emergency Department Care of the Patient with Acute Stroke53. Intravenous Thrombolysis54. Antithrombotic Therapy for Treatment of Acute Ischemic Stroke55. General Stroke Management and Stroke Units56. Critical Care of the Patient with Acute Stroke, 57. Pharmacologic Modification of Acute Cerebral Ischemia58. Treatment of "Other" Stroke Etiologies59. Medical Therapy of Intracerebral and Intraventricular Hemorrhage60. Rehabilitation and Recovery of the Patient with Stroke61. Interventions to Improve Recovery after Stroke62. Enhancing Stroke Recovery with Cellular Therapies63. Antiplatelet Therapy for Secondary Prevention of Stroke64. Secondary Prevention of Cardioembolic Stroke65. Design of Stroke-Related Clinical TrialsPart B: Interventional Therapy66. Endovascular Therapy of Extracranial and Intracranial Occlusive Disease67. Endovascular Treatment of Acute Ischemic Stroke68. Endovascular Treatment of Intracranial Aneurysms69. Interventional Therapy of Brain and Spinal Arteriovenous Malformations70. Dural Arteriovenous MalformationsPart C: Surgical Therapy71. Surgery of Anterior and Posterior Aneurysms72. Surgery for Intracerebral Hemorrhage73. Management of Intraventricular Hemorrhage74. Surgical Management of Cranial and Spinal Arteriovenous Malformations75. Surgical Management of Cavernous Malformations and Venous Anomalies76. Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis77. Extracranial to Intracranial Bypass for Cerebral Ischemia78. Decompressive Craniectomy for Infarction and Hemorrhage

Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022). Arthur L. Day, MD, is a board-certified and fellowship-trained neurosurgeon with specific cerebrovascular and skull-base neurosurgery expertise. He specializes in the microsurgical treatment of brain tumors and minimally invasive spinal surgery. Dr. Day is also a professor in the Vivian L. Smith Department of Neurosurgery at McGovern Medical School at UTHealth Houston.

"The book covers the basic gross anatomy with histopathology and etiopathogenesis of different types of strokes. The best aspect is the very well organized elaboration of disease characteristics with pathophysiological changes through to treatment." --© Doody’s Review Service,2021,Ram K Saha, M.D. (Thomas Jefferson University) Score: 92-4 Stars!

• Section 1 Pathophysiology1. Cerebral Vascular Biology in Health and Disease2. Mechanisms of Thrombosis and Thrombolysis3. Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease4. Histopathology of Brain Tissue Response to Stroke and Injury5. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death6. Intracellular Signaling: Mediators and Protective Responses7. The Neurovascular Unit and Responses to Ischemia8. Mechanisms of Damage After Cerebral Hemorrhage9. White Matter Pathophysiology10. Cerebral Ischemia and Inflammation11. Mechanisms of Plasticity, Remodeling and Recovery12. Genetics and Vascular Biology of Brain Vascular Malformations13. Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and DementiaSection 2 Epidemiology and Risk Factors14. Global Burden of Stroke15. Stroke Disparities16. Risk Factors and Prevention17. Prognosis after Stroke18. Vascular Dementia and Cognitive Impairment19. Genetic Basis of Stroke Occurrence, Prevention and OutcomeSection 3 Clinical Manifestations20. Classification of Ischemic Stroke21. Clinical Scales to Assess Patients with Stroke22. Carotid Artery Disease23. Anterior Cerebral Artery Disease24. Middle Cerebral Artery Disease25. Posterior Cerebral Artery Disease26. Vertebrobasilar Disease27. Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease28. Intracerebral Hemorrhage29. Aneurysmal Subarachnoid Hemorrhage30. Arteriovenous Malformations and Other Vascular Anomalies31. Stroke and Other Vascular Syndromes of the Spinal CordSection 4 Specific Conditions and Stroke32. Cardiac Diseases33. Atherosclerotic Disease of the Proximal Aorta34. Stroke Related to Surgery and Other Procedures35. Arterial Dissection, Fibromuscular Dysplasia, and Carotid Web36. Inflammatory and Infectious Vasculopathies37. Reversible Cerebral Vasoconstriction Syndromes38. Posterior Reversible Encephalopathy Syndrome39. Stroke and Substance Abuse40. Moyamoya Disease41. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy42. Hematologic Disorders and Stroke43. Migraine and Stroke44. Cryptogenic Stroke45. Cerebral Venous ThrombosisSection 5 Diagnostic Studies46. Ultrasonography47. Computed Tomography-Based Evaluation of Cerebrovascular Disease48. Magnetic Resonance Imaging of Cerebrovascular Diseases49. Cerebral Angiography50. OMICs in Stroke: Insight into stroke through epigenomics, transcriptomics, proteomics, lipidomics, and metabolomicsSection 6 TherapyPart A: Medical Therapy51. Stroke Systems of Care and Impact on Acute Stroke Treatment52. Prehospital and Emergency Department Care of the Patient with Acute Stroke53. Intravenous Thrombolysis54. Antithrombotic Therapy for Treatment of Acute Ischemic Stroke55. General Stroke Management and Stroke Units56. Critical Care of the Patient with Acute Stroke, 57. Pharmacologic Modification of Acute Cerebral Ischemia58. Treatment of "Other" Stroke Etiologies59. Medical Therapy of Intracerebral and Intraventricular Hemorrhage60. Rehabilitation and Recovery of the Patient with Stroke61. Interventions to Improve Recovery after Stroke62. Enhancing Stroke Recovery with Cellular Therapies63. Antiplatelet Therapy for Secondary Prevention of Stroke64. Secondary Prevention of Cardioembolic Stroke65. Design of Stroke-Related Clinical TrialsPart B: Interventional Therapy66. Endovascular Therapy of Extracranial and Intracranial Occlusive Disease67. Endovascular Treatment of Acute Ischemic Stroke68. Endovascular Treatment of Intracranial Aneurysms69. Interventional Therapy of Brain and Spinal Arteriovenous Malformations70. Dural Arteriovenous MalformationsPart C: Surgical Therapy71. Surgery of Anterior and Posterior Aneurysms72. Surgery for Intracerebral Hemorrhage73. Management of Intraventricular Hemorrhage74. Surgical Management of Cranial and Spinal Arteriovenous Malformations75. Surgical Management of Cavernous Malformations and Venous Anomalies76. Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis77. Extracranial to Intracranial Bypass for Cerebral Ischemia78. Decompressive Craniectomy for Infarction and Hemorrhage