Radiosurgery of the Skull Base: A Case-Based Approach

Siviero Agazzi is Chief of Cranial Surgery and Chief of Radiosurgery at the University of South Florida and has a 15 year experience of training residents and fellows in the fields of open skull base surgery and radiosurgery for skull base diseases. He is also serving as vice president of the North American Skull Base Society. Lawrence B. Berk is the primary Radiation Oncologist for CNS tumors at the University of South Florida. Together with Dr Agazzi and the other University of South Florida Neurosurgeons, has performed hundreds of base of skull radiosurgeries using Cyberknife and Tomotherapy. Former Vice Chair of the national cooperative research group, the Radiation Therapy Oncology Group (now NRG-Oncology), as well as former chair of the Symptom Management Committee of the RTOG. Served as the Chair of the Quality of Life program of the annual American Society of Radiation Oncology (ASTRO) annual meeting. Editor of Dying and Death in Oncology, Springer. Mohammad Hassan Noureldine received his Medical Degree from the Lebanese American University (LAU) in 2016 and a master's degree in Neuroimaging from Lebanese University (LU) in 2018. He graduated in 2012 with a bachelor's degree in biology and minor in chemistry from LAU and received a University Diploma in clinical research in 2014 from LU. In 2018, he joined the Department of Neurosurgery at Johns Hopkins All Children's Hospital (JHACH) as a postdoctoral research fellow and currently completing a surgical internship at the University of South Florida.

• SECTION 1 Skull Base Radiosurgery: The Basics1. Stereotactic Radiosurgery Machines2. Fundamentals of Radiobiology for Radiosurgery3. Stereotactic Radiosurgery/Radiotherapy with Particle Therapy4. Dose Tolerances of Normal Tissues in Skull Base RadiosurgerySECTION 2 Olfactory Groove/Planum Sphenoidale/Paranasal Region5. Esthesioneuroblastoma - Delayed Postoperative Radiosurgery for Recurrence at Short-Term6. Esthesioneuroblastoma - Delayed Postoperative Radiosurgery for Recurrence at Long-Term7. Olfactory Groove Meningioma - Upfront Radiosurgery8. Planum Sphenoidale Meningioma - Upfront Radiosurgery9. Planum Sphenoidale/Orbital Roof Meningioma - Delayed Postoperative Radiosurgery for Recurrence10. Paranasal Sinus Melanoma - Definitive Stereotactic Body Radiation TherapySECTION 3 Sellar/Suprasellar/Parasellar Region - Pituitary Adenoma11. Null Cell - Delayed Postoperative Radiosurgery for Growing Intracavernous Residual12. Null Cell - Delayed Postoperative Radiosurgery for Growing Perioptic Residual13. ACTH Secreting - Delayed Postoperative Radiosurgery of Gland for Recurrent Pathology-Negative Cushing Disease14. Growth Hormone Secreting - Immediate Postoperative Radiosurgery for Residual15. Prolactinoma - Immediate Postoperative Radiosurgery for ResidualSECTION 4 Sellar/Suprasellar Region - Other Than Pituitary Adenoma16. Craniopharyngioma - Delayed Postoperative Radiosurgery for Recurrence17. Tuberculum Sella Meningioma - Upfront Radiosurgery18. Suprasellar Meningioma - Immediate Postoperative Radiosurgery for Residual19. Suprasellar Non-Small Cell Lung Carcinoma Metastasis - Upfront RadiosurgerySECTION 5 Parasellar Space/Cavernous Sinus Region20. Trigeminal Schwannoma - Upfront Radiosurgery21. Trigeminal Schwannoma - Upfront, StagedVolume Radiosurgery22. Cavernous Sinus Meningioma - Upfront Radiosurgery23. Cavernous Sinus Meningioma - Immediate Postoperative Radiosurgery for Perioptic Residual24. Cavernous Sinus Meningioma - Immediate Postoperative Radiosurgery for Residual Tumor After Repeat ResectionSECTION 6 Clivus/Petroclival Junction25. Chondrosarcoma - Definitive Radiosurgery After Subtotal Resections26. Chordoma - Immediate Postoperative/PostProton Therapy Radiosurgery for Residual Disease27. Cavernous Sinus/Petroclival Meningioma - Immediate Postoperative Radiosurgery for Residual/Postoperative Radiosurgery for Recurrence28. Chondrosarcoma/Trigeminal Neuralgia - Upfront, Multisession Radiosurgery/Postoperative Radiosurgery for Trigeminal NeuralgiaSECTION 7 Cerebellopontine Angle Region - Other Than Vestibular Schwannoma29. Petrous Apex Meningioma - Upfront Radiosurgery30. Sphenopetroclival Meningioma - Delayed Postoperative Radiosurgery for Growing Residual31. Petrous Ridge/Sigmoid Sinus Meningioma - Upfront Radiosurgery32. Petrosal Surface/Sigmoid Sinus Meningioma - Delayed Postoperative Multisession Radiosurgery for Growing Residual33. Endolymphatic Sac Tumor - Immediate Postoperative Radiosurgery of Surgical Bed34. Cisternal Trigeminal Schwannoma - Upfront Radiosurgery35. Trochlear Schwannoma - Upfront RadiosurgerySECTION 8 Internal Auditory Canal/Cerebellopontine Angle Region - Vestibular Schwannoma and Facial Schwannoma36. Medium Vestibular Schwannoma without Hearing Deficit - Upfront Radiosurgery37. Medium Vestibular Schwannoma with Hearing Deficit - Upfront Radiosurgery38. Large Vestibular Schwannoma - Immediate Postoperative Radiosurgery for Residual39. Large Vestibular Schwannoma - Delayed Postoperative Radiosurgery for Growing Residual40. Small Vestibular Schwannoma with Hearing Deficit - Upfront Radiosurgery41. Small Facial Schwannoma with Hearing Deficit - Upfront RadiosurgerySECTION 9 Trigeminal Neuralgia42. Trigeminal Neuralgia due to Microvascular Conflict - Upfront Radiosurgery43. Idiopathic Trigeminal Neuralgia - Upfront Radiosurgery44. Trigeminal Neuralgia due to Trigeminal Schwannoma - Upfront Radiosurgery45. Trigeminal Neuralgia due to Petroclival Meningioma - Upfront RadiosurgerySECTION 10 Jugular Foramen Region46. Capillary Hemangioma - Postoperative Radiosurgery for Residual Tumor47. Jugular Foramen/Sigmoid Sinus Meningioma - Postoperative Radiosurgery for Residual Tumor48. Jugular Foramen Meningioma - Upfront Radiosurgery49. Jugular Paraganglioma - Postoperative Radiosurgery for Residual Tumor50. Jugular Paraganglioma - Upfront Radiosurgery51. Vagal Schwannoma - Postoperative Radiosurgery for Residual Tumor52. Jugular Foramen Schwannoma - Upfront Radiosurgery53. Jugular/Clival Paraganglioma - Delayed Postembolization, Multisession Radiosurgery for Growing ResidualSECTION 11 Foramen Magnum/Clivus Region54. Foramen Magnum Meningioma - Upfront Radiosurgery55. Foramen Magnum/Petroclival Meningioma - Immediate Postoperative Radiosurgery for Residual56. Occipital Condyle/Clivus/C1 Vertebra Metastasis - Upfront Stereotactic Body Radiation TherapySECTION 12 Major Sinuses57. Superior Sagittal/Transverse Sinuses Meningioma - Immediate Postoperative, Staged-volume Radiosurgery for Residual/Delayed Postoperative Radiosurgery for Growing Residual58. Superior Sagittal Sinus Meningioma - Delayed Postoperative, Multisession Radiosurgery for Growing Residual59. Superior Sagittal Sinus Meningioma - Immediate Postoperative Radiosurgery for Residual60. Torcular/Tentorial Meningioma - Upfront Radiosurgery61. Transverse Sinus Dural Arteriovenous Fistula - Upfront, Preembolization Radiosurgery62. Tentorial Dural Arteriovenous Fistula - Upfront Radiosurgery