Dr. Julio A. Chirinos, MD, PhD, is an Associate Professor of Medicine and Director of the Arterial Hemodynamics and Cardiac Imaging Quantification Core Laboratory at the University of Pennsylvania Perelman School of Medicine. Dr. Chirinos directs an NIH-funded research program focused on the role of arterial stiffness and ventricular arterial interactions in heart disease, mechanisms of human heart failure and the use of proteomics to discern mechanisms of human heart failure. He currently leads clinical studies and trials designed to therapeutically target the arterial tree in order to reduce maladaptive cardiac remodeling, diastolic dysfunction, and to treat patients with Heart Failure and Preserved Ejection Fraction, an epidemic condition for which no effective proven pharmacologic therapies are currently available. He also leads various cohort studies with deep cardiovascular phenotyping aimed at characterizing phenotypic profiles in humans. Dr. Chirinos also directs a core analysis laboratory for assessments of cardiac and arterial structure and function with non-invasive imaging, which has served as the core lab for various multicenter studies. His laboratory utilizes a combination of imaging modalities (including arterial tonometry, echocardiography and cardiac MRI) coupled with modeling approaches to characterize arterial physiology and ventricular-arterial interactions in humans. Dr. Chirinos has published >200 papers, chapters, reviews, and editorials and has been an invited speaker in >120 scientific sessions. He has participated in various clinical expert committees for the American Heart Association, American Society of Echocardiography, European Society of Cardiology, American Society of Hypertension, European Association of Cardiovascular Imaging and the Lancet Commission for Hypertension. Dr. Chirinos is currently the Vice-President of the North American Artery society, which promotes the study of arterial function as a determinant of cardiovascular disease. He is an Associate Editor of Circulation Heart Failure and a former Editor of the Cochrane Group (Cochrane Collaboration), Senior Consulting Editor of the Journal of the American College of Cardiology – Cardiovascular Imaging, Associate Editor for the Journal of Clinical Hypertension and member of the editorial board of Pulse and the Journal of Geriatric Cardiology. He is also a Visiting Professor at the University of Ghent in Belgium, where he maintains an active collaboration with the Asklepios Investigators aimed at characterizing arterial aging at the population level.

• Section I. Biophysical and Technical Principles1. Basic Principles of pulsatile pressure and flow phenomena in elastic vessels2. Measurements of arterial pressure and flow in vivo3. Essential Principles of Pulsatile Pressure-flow relations in the arterial tree4. Magnetic Resonance Imaging for the assessment of aortic stiffness and pulsatile hemodynamics5. Computed tomography of the aorta6. Radionuclide-based Imaging of the aortic wall7. Arterial wall stiffness: basic principles and methods of measurement in vivo8. Ambulatory measurements of pulsatile hemodynamics9. Animal Models and Ex-vivo Methods to Study Arterial StiffnessSection II. Basic and Applied Physiology10. Hemodynamic role of the Aorta11. Wave Reflections in the arterial tree12. Linking Arterial Stiffness to Microvascular Remodeling13. Myocardial function: from myofilaments to cardiac pump14. Systolic-diastolic coupling15. Ventricular-arterial coupling: The pressure-volume plane16. Myocardial wall stress and the systolic loading sequence17. Assessment of Ventricular Arterial Interactions via arterial pressure-flow relations in humans18. Hemodynamic Determinants of Myocardial Oxygen Demand and SupplySection III. Biologic pathways leading to arterial stiffness and dysfunctional pulsatile hemodynamics19. Role of elastin and elastin-derived peptides in arterial stiffness: from synthesis to potential therapeutic interventions20. Inflammation and arterial stiffness21. Mechanisms of Aortic Wall Calcification22. Vascular smooth muscle dysfunction and arterial stiffness23. Endothelial cell dysfunction and Senescence: Biologic mechanisms and Hemodynamic consequences24. Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics25. Cellular mechanisms of ageing and their impact on the aortic/arterial wallSECTION IV. Clinical significance of arterial stiffness and pulsatile hemodynamics26. Normal Aging: Arterial Stiffness and remodeling over the life course27. Early Vascular Aging and Supernormal Vascular Aging: Genetics, Epigenetics, and Environment28. Ethnic differences in arterial stiffness and central aortic hemodynamics29. Arterial Stiffness and Pulsatile hemodynamics in Systemic Hypertension30. Arterial Stiffness and Pulsatile hemodynamics in Diabetes and Obesity31. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in the USA and Europe32. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in Asia33. Arterial Stiffness, Cardiovascular Risk and Strategies for enhancing risk Stratification34. Role of the arterial tree in Physiologic Adaptations to exercise35. Invasive Hemodynamic Assessments during exercise: Normal patterns and clinical value36. Arterial Stiffness and Pulsatile hemodynamics in Heart Failure with Reduced and Preserved Ejection Fraction37. Ventricular-Arterial Coupling and Arterial Load in Aortic Valvular Disease38. Arterial Stiffness and Atherosclerosis: Mechanistic and Pathophysiologic Interactions39. Arterial Stiffness and Pulsatile hemodynamics in Coronary Artery Disease and other forms of Atherosclerotic vascular diseases40. Arterial Stiffness and Pulsatile hemodynamics in Renal disease41. Arterial Stiffness, Pulsatile hemodynamics, Cognitive dysfunction42. Arterial Stiffness and Pulsatile hemodynamics in pregnancy and pregnancy-related vascular complications 43. Arterial Stiffness and Pulsatile Hemodynamics in Pediatric populations44. Aortopathies and Arteriopathies45. Pulsatile hemodynamics and arterial stiffness in primary aortopathies46. Arterial Hemodynamics and Pulsatile Hemodynamics in Congenital Heart Disease47. Arterial Stiffness and Pulsatile Hemodynamics in Acute and Chronic Infectious Diseases48. Arterial Stiffness, Hemodynamics and Microvascular Complications in conditions characterized by low arterial pulsatilitySECTION V. Therapeutic approaches to improve arterial stiffness and pulsatile hemodynamics49. Effects of common antihypertensive treatments on pulsatile arterial hemodynamics50. Pharmacologic approaches to reduce arterial stiffness51. Organic and dietary nitrates, inorganic nitrite, NO donors, and sGC stimulation52. Effect of Exercise Training and Weight Loss on Arterial Stiffness and Pulsatile Hemodynamics53. Dietary Salt and Arterial Stiffness54. Role of Arterial Stiffness and Central Hemodynamics in Personalized medicine in hypertensionSection VI. Arterial Stiffness and Pulsatile Hemodynamics in the Pulmonary Circulation55. Pulsatile hemodynamics and Ventricular-Arterial Interactions in the pulmonary circulation: Physiologic Concepts56. Pulmonary arterial load and its impact on the right ventricle in pulmonary hypertension57. Biologic mechanisms and consequences of pulmonary artery stiffening in Pulmonary Hypertension58. Therapeutic approaches to improve right ventricular load