Biochemistry of Drug Metabolizing Enzymes

Dr. Akash is currently working as an Associate Professor at the Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. He got his PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of endocrine disruptingchemicals on various molecular and metabolic pathways that are involved in metabolic disorders and their treatment strategies. His research work is cutting-edge and worthy of extension in developing countries, like Pakistan, where it can be most beneficial and cost-effective, especially for diabetic patients. Based on his significant scientific contributions inthe field of Pharmaceutical Sciences, he has been awarded “Research Productivity Awards” from the Pakistan Council for Science and Technology, the PAS Gold Medal from the Pakistan Academy of Sciences, and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan. Dr. Kanwal Rehman is working as an Associate Professor at the Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Rehman received her PhD in Pharmacology from Zhejiang University, China. She nurturesa keen interest in the pathogenesis of metabolic disorders and new therapeutic modalities for its treatment. Currently, sheis focusing on the investigation of the role of pharmacogenomics based upon gene polymorphism on various molecular andmetabolic pathways that are involved in mitogenic disorders and treatment strategies, like natural biogenic compounds against different risk factors of metabolic disorders, including pancreatitis, cardiometabolic disorders, and hormonal imbalance. Dr. Rehman has also been awarded the Research Productivity Award by the Pakistan Council for Science and Technology, Pakistan; the PAS Gold Medal from the Pakistan Academy of Sciences; and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan.

• 1. Biochemical activation of drug metabolizing enzymes: From mechanism of action to functions2. Computational approaches and drug metabolizing enzymes: Concepts and challenges3. Biotransformation of drugs by drug metabolizing enzymes: Concepts and challenges4. Emerging environmental contaminants and drug metabolizing enzymes: Retrospective analysis and prospects5. Impact of prodrugs on drug metabolizing enzymes: From function to regulation6. Impact of hormones on drug metabolizing enzymes: From function to regulation7. Impact of receptors on drug metabolizing enzymes: From function to regulation8. Biochemistry of cathepsin enzymes and metabolic functions in lysosome9. Fate of drug metabolizing enzymes in metabolic diseases: Challenges and strategies10. Fate of drug metabolizing enzymes in cardiovascular diseases: Challenges and strategies11. Fate of drug metabolizing enzymes in neurological diseases: Challenges and strategies12. Impact of physiological factors on drug metabolizing enzymes: Challenges and strategies13. Xenobiotics and drug metabolizing enzymes: Challenges and strategies14. Drug metabolizing enzymes and inflammatory responses: Mechanism of induction and treatment strategies15. Polymorphism and drug metabolizing enzymes: Challenges and strategies16. Modulation of human microbiome and drug metabolism: Current trends and future prospects17. Bioanalytical techniques for prediction of metabolic activity of drug metabolizing enzymes: Challenges18. Role of pharmacogenomics for prediction of personalized medicines: Concepts and challenges19. Dietary sources of drug metabolizing enzymes: From production to regulation20. Vitamin deficiencies and drug metabolizing enzymes: Challenges and strategies21. Malnutrition and Drug metabolizing enzymes: Challenges and strategies22. Drug metabolizing enzymes and oxidative stress: Mechanism of induction and treatment strategies