Endocrine Hypertension

Professor Pappachan M Joseph is a senior consultant Endocrinologist in the UK and honorary professor at the Manchester Metropolitan University, UK & Manipal University, India. He is an associate editor to Frontiers in Clinical Diabetes & Healthcare, the World Journal of Diabetes, Current Drug Safety, and TouchREVIEWS in Endocrinology. He is also in the editorial board member to JCEM Case Reports (American Endocrine Society) & Scientific Reports (Nature.com). He has fully edited multiple journal issues in the past, and is the lead editor to Elsevier Textbooks: “Endocrine Hypertension: From Basic Science to Clinical Practice” - 2022 and "Metabolic Dysfunction-Associated Fatty Liver Disease" (Endocrine & Metabolism Clinics) - 2023. He has more than 200 scientific publications in his credit in peer reviewed journals/textbooks and has several multinational research collaborations including the Cochrane Metabolic & Endocrine Disorders Group. His academic h-index is 45 with more than 6500 citations of his works to date. His clinical and academic excellence was recognised by the National Clinical Impact Award of the British Government in 2024. His research special interests include obesity, metabolic disorders including MAFLD, neuroendocrinology & parathyroid disorders. Dr. Cornelius James Fernandez MD, MRCP is a consultant endocrinologist at Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK. He graduated from Kottayam Medical College, and underwent internal medicine postgraduate training from Coimbatore Medical College (India) with further specialist training in Endocrinology in the U.K. He is a review editor to “Frontiers in Clinical Diabetes and Healthcare” and scientific peer reviewer to several other medical journals. He has authored 35 peer reviewed scientific papers to date in different medical journals and actively involves in clinical research programs in his hospital. His research special interests include endocrine hypertension, diabetic foot disease and diabesity.

"The endocrine system is a complex creation, which maintains homeostasis in the body. Blood pressure, a physiological presence, ensures that the body a health entity. Hormones and blood pressure have a multifactorial relationship, characterized by “quantum, entanglement” at various levels. The causation, clinical features, comorbid conditions, complications and concerns of hypertension are linked closely with the endocrine system. In turn, knowledge of endocrinology provides a compass to understand and navigate the heterogeneity of hypertension. The book simplifies this structure and brings clarity to this complex discipline. “From basic science to clinical practice”, it systematically covers the adrenal and renal causes of hypertension, the contribution of the pituitary, thyroid and parathyroid glands, and the increasing role of metabolic disorders like obesity, insulin resistance and obstructive sleep apnea in the syndrome. The writers engage the reader in a journey through the wonderous world of physiology of blood pressure and pathogenesis of hypertension. Each page that I turn, each chapter that I read makes me feel like Alice in Wonderland, learning a new facet of health and disease. Endocrine hypertension is a book that I would commend to all health care professionals dealing with hypertension, both primary and secondary, and strongly recommend to students and clinicians of endocrinology and vascular medicine." --Dr. Sanjay Kalra"I read with interest the textbook Endocrine Hypertension edited by J. "M. Pappachan and C. J. Fernandez. The preparation of this book involves the participation of many leading scientists and clinicians that dedicated their studies to understanding the genetics and pathophysiology of the different hormonal systems involved in the regulation of blood pressure and the identification of the best clinical approaches for the management of the endocrine forms of hypertension.The present textbook should be therefore, of special interest not only for endocrinologists but for all categories of clinicians that are involved in the management of patients with hypertension, including general practitioners, internists, cardiologists, nephrologists and paediatricians.I predict that this book will be read with interest by many colleagues and should be used to support the specific learning of medical students and fellows." --Paolo Mulatero"This comprehensive textbook on endocrine hypertension is a delight to read. The chapters are laid out very well with each topic covering the basic physiology and pathophysiology of endocrine hypertension. The flow charts, colourful graphical abstracts and tables make the reading and understanding of the complex clinical scenarios much easier. I am impressed with several of the authors who are internationally acclaimed and pioneers in the field whose contributions no doubt add tremendous value to the book. I no doubt feel this is a very useful textbook for any practicing consultant or trainee dealing with hypertension in general medicine and endocrinology." --Ganesan Arunagirinathan*4 stars* "...a comprehensive resource for understanding endocrine-related causes of secondary hypertension…. [W]ell organized [with] excellent diagrams and tables… to inform readers of the unique clinical features or lab abnormalities that might signal an endocrine root cause, leading to more effective treatment and prevention. This book will be of great benefit for students, medical trainees at all levels, as well as clinicians in primary care, cardiology, nephrology, and endocrinology… and those who study hypertension in research, pharmaceutical, or clinical settings. This is a collaborative resource with expert contributors from all around the world,… [and] is highly recommended for all who see a fair portion of hypertension in their clinical setting or in clinical training..." --©Doody’s Review Service, 2023, Prathayini Subarajan, DO (Loyola University Stritch School of Medicine)

• 1. Endocrine hypertension – an overview2. Catecholamines and blood pressure regulation3. Adrenal Cortical Hormones and Blood Pressure Regulation4. Hypothalamic-Pituitary-Adrenal Axis and Blood Pressure Regulation5. Renin-Angiotensin-Aldosterone System and blood pressure regulation6. Monogenic Hypertension – an overview7. Primary Aldosteronism (Conn’s syndrome)8. Familial Hyperaldosteronism9. Congenital Adrenal Hyperplasia and Hypertension10. Endocrine Hypertension: Discovering the Inherited Causes11. Pheochromocytomas and Hypertension12.Paragangliomas and hypertension13. ACTH dependent Cushing Syndrome14. Adrenal Cushing’s syndrome15. Hypertension in Growth Hormone Excess (Acromegaly) and Deficiency16. Hypertension in Thyroid disease & hyperparathyroidism17. Obesity, Insulin Resistance, and Obstructive Sleep Apnoea18. Endocrine Hypertension in Children19. Endocrine Hypertension in Pregnant Woman20. Imaging for Patients with Endocrine Hypertension21. Systematic Approach for the Diagnosis and Management of Endocrine Hypertension