Lantibiotics as Alternative Therapeutics

Dr. Sanket Joshi is currently a Professor at the Amity Institute of Microbial Technology, Amity University, Rajasthan, India. He has academic teaching and research experience of about 16 years, and industrial R&D experience of about 4 years in India and Oman. While working in Indian pharma companies, he undertook several turnkey projects. His current research interests encompass energy (In-situ/ex-situ microbial enhanced light/heavy oil recovery; chemical enhanced oil Recovery; biofuels), microbial products (biosurfactants, biopolymers, R&D and scale-up), and environmental bioremediation (crude oil pollution; analysis, mitigation and control of souring by Sulfate reducing bacteria; HPAM contaminated sites). He has about 125 scientific publications in international journals, book chapters, and conference proceedings, and two books to his credit. He is an Academic/Associate Editor for: Frontiers in Microbiology, PeerJ, Ecotoxicology (Springer), Petroleum Science and Technology (Springer), Biotech (Springer), and Open Biotechnology Journal; guest editor for Frontiers in Microbiology, Sustainability, Scientifica, and Open Biotechnology Journal. Dr. Kar is a Scientist at Technische Universität Berlin, Institute for Chemistry, Germany. He works in the Bio-Molecular Modelling Group, on application of classical and quantum mechanical simulations in collaboration with experimental measurements to explore the mechanistic details in flavin-based bifurcating system. He previously worked as a Post-Doctoral Fellow in Fritz Haber Center for Molecular Dynamics Research, in group of Dr. Igor Schapiro, Hebrew University of Jerusalem, Israel. [Apr 2017 – Jun 2020], and as a Project Assistant in Department of Biophysics, Bose Institute, Bose Institute, Kolkata. [July 2011 – Jan 2012]. He received various awards/scholarships. He has more than 55 publications in journals of international reputes, conferences, and book chapters, to his credit. Dibyajit Lahiri, PhD, is Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. His research focuses on biofilm formation on human prostheses and its inhibition through phytochemical and nanocompound interventions, with particular interest in the molecular mechanisms by which natural compounds disrupt biofilm integrity. His work also encompasses computational drug development using bioinformatics approaches. Dr. Lahiri has authored over 100 publications, has edited academic volumes in his field, and serves as Associate Editor for multiple international peer-reviewed journals.Moupriya Nag, PhD, is an Associate Professor in the Department of Biotechnology at UEM, Kolkata. Her research interests include single molecule biophysics, particularly protein unfolding/refolding and protein aggregation kinetics. She has expertise in biophysical chemistry, photochemistry, and single molecule spectroscopy, and has worked on protein-ligand interactions and in-vitro detection of metal ions. Her postdoctoral work explored peptide aggregation kinetics related to neurodegenerative diseases. Currently, her research focuses on functional amyloids in bacteria and their role in biofilm formation.

• 1. Genetics of the development of antibiotic and multi-drug resistance2. Antimicrobial peptides and the potent mechanism of action3. Lantibiotics and Gene regulation 4. Biosynthesis of Lantibiotics5. Optimizations in the productions of Lantibiotics and Scale-Up6. Analytical Techniques in Identifying & Purifying the proteins7. Development of Recombinant Lantibiotics and their Potent Uses8. Mechanism of Action of the Lantibiotics on the Multi-Drug Resistant Organism9. Mechanism of inhibiting Biofilm associated Chronic Infections by Lantibiotics10. Lantibiotics & Its Role in Food Preservation11. In-Silico studies of the Interaction of Lantibiotics with Virulent Proteins12. Insights at the atomistic resolution of Lantibiotics using Multiscale Simulations13. Case studies: Applications of such novel drugs14. Recent updates in understanding of molecular genetics of lantibiotics production15. In silico molecular modelling approach for better designing and applications16. Marine microbes as a potential source of novel drugs17. Combinations of nano-bio molecules as next generation antimicrobial agents