Angiotensin

Paul M Pilowsky began BMedSci(Hons), BMBS, PhD his career as a graduate student investigating, inter alia, the role of brainstem and spinal cord pathways in the control of blood pressure with a focus on serotonin. His work has now been cited more than 5000 times and published in major Journals including the Journal of Neuroscience, the Journal of Comparative Neurology and the British Journal of Pharmacology. A hallmark of his work has been the adoption of, and combination of, novel approaches to address difficult questions. He pioneered the use of combining single cell electrophysiology in vivo with immunohistochemistry. His development of isotype selective monoclonal antibodies to phosphorylated tyrosine hydroxylase enabled the detection of tyrosine hydroxylase positive presympathetic neurons in the brainstem that had become excited. He was responsible for the initial development of a new medical school at Macquarie University in Sydney. His service to Neuroscience was recognised by the award of the Australian Neuroscience Medal. He mentored 26 graduate students to on-time completion, and mentored 24 post-Doctoral Fellows, many of whom now have their own established careers.In imagining this book, it was felt that a departure from the usual highly focussed text would be of interest. Hence, a multi-Author volume has been created that reveals the multiple facets of a neurotransmitter with very broad actions.

“…an excellent resource in the series on Molecular Mediators in Health and Disease, covering how cells communicate from the perspective of individual mediators… [with] interesting details on the renin- angiotensin-aldosterone system (RAAS) and development of drugs that block the formation of angiotensin to manage hypertension; the detection of functional renin-angiotensin systems existing locally in the tissue; the discovery of angiotensin (1-7); and the identification of angiotensin- converting enzyme 2 (ACE2) as a receptor for the coronavirus that causes COVID-19…. [T]he book is very much needed…. [and] includes several colored illustrations which facilitate easier understanding of this complex subject…. [A]n excellent reference for students, researchers in life sciences, and clinicians, especially nephrologists and others interested in the diverse functions of the angiotensin system.” --©Doody’s Review Service, 2023, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

• ForewordPaul M. Pilowsky1. Regulation of sympathetic nerve activity by the central angiotensin system in heart failureRohit Ramchandra and Julia Shanks2. The contribution of angiotensin peptides to cardiovascular neuroregulation in health and diseaseEwa Krystyna Szczepańska-Sadowska, Tymoteusz Żera and Agnieszka Cudnoch-Jedrzejewska3. Renin Angiotensin System and inflammationAna Cristina Simões e Silva, Leticia Bitencourt, Juliana Lacerda de Oliveira Campos, Bruna Luisa Fischer, Pedro Alves Soares Vaz de Castro and Stephanie Bruna Camilo Soares de Brito4. Targeting Renin Angiotensin System: A strategy for drug development against neurological disordersBharat Bhusan Subudhi and Pratap Kumar Sahu5. Pharmacology of Angiotensin in renovascular systemGaaminepreet Singh, Kirti Gupta, Newly Bagang, Sandeep Arora, Onkar Bedi, Manish Kumar and Shubham Yadav6. The Role of Angiotensins in the Pathophysiology of Human PregnancyKirsty G. Pringle, Eugenie Lumbers, Saije Morosin and Sarah Delforce7. Hematopietic bone marrow renin-angiotensin system in health and diseaseIbrahim Celalettin Haznedaroglu and Umit Malkan8. Angiotensin II as a mediator of renal fibrogenesisGunter Wolf and Ivonne Löffler9. ANGIOTENSIN AND ATHEROSCLEROTIC VASCULAR DISEASEDelia Salaru, Cristina Adam, Dragos Marcu, Radu Sascau and Cristian Statescu10. ACE2 in pulmonary diseasesHongpeng Jia and Qing Lin11. Renin Angiotensin Aldosterone System Inhibitors. New and Old ApproachesCarlos Maria M Ferrario, Jessica L. VonCannon, Kendra N. Wright and Sarfaraz Ahmad12. Aspects of the Intracellular Renin-Angiotensin SystemMark Chappell, Liliya Yamaleyeva, Hossam Shaltout and TanYa Gwathmey-Williams13. Drugs affecting the angiotensin system in COVID19Fouad M. Zouein14. ANGIOTENSIN II AND ITS ACTION WITHIN THE BRAIN DURING HYPERTENSIONSrinivas Sriramula and Vinicia Campana Biancardi15. Morphological Aspect of the Angiotensin Converting Enzyme ACE2 Ken Yoshimura, Yasuo Okada, Shuji Toya, Shin-Ichi Iwasaki and Tomoichiro Asami16. Angiotensin in the eyeDulce Elena Casarini Sr.17. Brain renin-angiotensin system in the injured brain: The role of astrocytes and microgliaAlberto Javier Ramos18. Angiotensin and COVID19Gaetano Alfano19. Transgenic animal models for the functional analysis of ACE2Michael Bader and Natalia Alenina20. Role of Angiotensin in Different MalignanciesAlok Chandra Bharti, Manoj Kumar Kashyap, Anjali Bhat, Divya Janjua, Rashmi Rao, Kulbhushan Thakur, Arun Chhokar, Nikita Aggarwal, Joni Yadav, Tanya Tripathi, Apoorva Chaudhary and Anna Senrung21. ACE2/Angiotensin-(1-7)/Mas Receptor Axis in the Central Nervous System: Physiology and PathophysiologyAline Miranda, Antonio Lucio Teixeira, Natalia Rocha, Milene Rachid and Eliana Toscano22. Therapeutic Potential of Angiotensin-(1-7)Patricia Elizabeth Gallagher, E. Ann E. Tallant and Ana Clara Melo23. Angiotensin and PainCristian Acosta, Alicia Seltzer, Sean Patterson and Susana Valdez24. Renin-angiotensin system and emotional stressMarco Antônio Peliky Fontes, Ana Cristina Simões e Silva and Lucas Kangussu25. Angiotensins in obesity: focus on white adipose tissueEliete Dalla Corte Frantz, Dangelo Magliano, Beatriz Alexandre-Santos and Vinícius Sepulveda-Fragoso26. Angiotensin in the gut: role in inflammatory bowel diseaseYan Chun Li27. The Renin-Angiotensin System in gastrointestinal functionsMaria Grazia Zizzo and Rosa Serio28. Angiotensin in shockEmily See, Yugeesh Lankadeva, Rinaldo Bellomo, Clive May29. Angiotensin II and astrocytes: relevance to psychiatric disordersClaudia Bregonzio30. Ang II in the kidney in polycystic kidney diseaseJacqueline Kathleen Phillips, Sheran Li and Shabarni Gupta31. The Role of Angiotensin Peptides in the Brain During Health and DiseaseDAVID WONG ZHANG, T. Michael De Silva and Christopher Sobey