Modern Diabetology

R. Paul Robertson, M.D. is an Emeritus Professor of Medicine at the University of Washington and at the University of Minnesota.Dr. Robertson has published 395 peer-reviewed manuscripts with primary emphasis on pancreatic islet function in humans, animals, and clonal cell lines. His early studies were the first to demonstrate defects involving the adverse effects of glucose toxicity on the critical insulin promoters Pdx-1 and MafA associated with glucose toxicity. More recent research demonstrated adverse metabolic consequences of using the liver as a transplant site for pancreatic islet transplantation in patients with type 1 diabetes mellitus and in autoislet recipients following pancreatectomy for chronic, painful pancreatitis.

• SECTION I Regulation of Gene Expression, Hormone Synthesis, and Hormone SecretionChapter 1 Pancreatic Development in the Context of DiabetesChapter 2 Glucagon: From Gene Regulation to SecretionChapter 3 Insulin Production, Processing, and SecretionChapter 4 Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIPSECTION II Hormone ActionChapter 5 Glucagon Synthesis, Secretion, and Mechanisms of ActionChapter 6 Insulin Structure and FunctionChapter 7 Common Mechanisms of Insulin Signaling, Action, and ResistanceChapter 8 Insulin Receptor Structure and FunctionChapter 9 Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on HumansChapter 10 Insulin Action in the BrainChapter 11 Insulin Action in the Cardiovascular SystemChapter 12 Metabolic Regulation by Adipokines, Hepatokines, and MyokinesSECTION III Genetics of DiabetesChapter 13 Genetics of Monogenic Forms of DiabetesChapter 14 Genetics of Type 1 DiabetesChapter 15 Genetics of Type 2 DiabetesSECTION IV Type 1 DiabetesChapter 16 Spotlight on the Pathology of Type 1 DiabetesSECTION V Type 2 DiabetesChapter 17 Heterogeneity of Type 2 Diabetes MellitusChapter 18 Cystic Fibrosis-Related DiabetesSECTION VI Complications of DiabetesChapter 19 Intranuclear Beta Cell Nrf2 Expression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early TreatmentChapter 20 Diabetic Retinal DiseaseChapter 21 Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic TargetsSECTION VII Pharmacology and DrugsChapter 22 SGLT2 Inhibitors and Slowing Kidney Disease Progression From DiabetesChapter 23 Advanced Technology in Diabetes: Sensors and PumpsChapter 24 Pancreas and Islet Cell Transplantation for DiabetesChapter 25 Stem Cell-Derived Islet Therapy for Type 1 Diabetes