T Cell Metabolism and Cancer Immunotherapy

T Cell Metabolism and Cancer Immunotherapy investigates the cellular regulation of T-cell immunity and tolerance. Most effort is being expended to develop and optimize strategies for utilizing highly reactive T lymphocytes for cell-based therapies. Because of the plasticity and potentially unlimited capacity for self-renewal, stem cell-derived T lymphocytes have great potential in the treatment of diseases including cancer. Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy.  By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity.Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy- Provides a summary of the current state-of-the-art, creating a valuable foundation for both established researchers and newcomers/students in the field in cancer immunotherapies- Focuses on the investigation of cellular regulation of T-cell immunity and tolerance- Defines the precise role and mechanism of T cell metabolism in modulating T cells and T cell-mediated immunity