Quick Guide to Body Fluid Testing

Darci Block PhD, DABCC completed her PhD in chemistry from North Dakota State University and clinical chemistry fellowship at the Mayo Clinic in 2009 and 2011, respectively. Since that time, she has been the co-medical director of the Central Clinical Laboratory at the Mayo Clinic in Rochester, USA. As it pertains to body fluid testing expertise, she has been the technical director of body fluid chemistry testing in a high volume core and reference laboratory, published in the peer reviewed literature on the subject of validating body fluid tests, authored two book chapters on the subject, developed a learning module on body fluids for the Area9 Learning Lab (AACC initiative), presented numerous times over the past 10 years at AACC through workshops and brown bag sessions on this subject, and served as vice chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018 Deanna Franke MT (ASCP), Ph.D., DABCC completed her PhD in microbiology and immunology from University of Louisville and clinical chemistry and toxicology fellowship at the University of Louisville in 2005 and 2007, respectively. She is currently the Director of Technical Specialties at Atrium Health in Charlotte, NC. As it pertains to body fluid testing expertise, she served as chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018, supported body fluid chemistry testing and informatics in a core laboratory, as well as presented AACC webinars and sessions.

"...a quick reference on body fluid testing, including analytic validation and pre- and post-analytic considerations…. [for] clinical laboratory scientists (in practice or in training) and supervisor/managers responsible for quality systems and quality and regulatory oversight. It will also be useful to health practitioners interested in (seemingly very esoteric) laboratory detail related to performing body fluid testing…. Elements of the book are also present in Clinical and Laboratory Standards Institute documents (i.e., C49 ED2, H56A, EP15-A3) and other standard laboratory medicine references (Tietz, Henry's)." --©Doody’s Review Service, 2023, Valerie L Ng, PhD MD (Alameda County Medical Center/Highland Hospital)

• Preanalytic Considerations - Body Fluid Test Formulary and Ordering Practices - Collection - Labeling - Handling and Transport - Specimen Assessment - Specimen Pretreatment - References Analytic Validation - Accuracy/Trueness - Linearity/Reportable Range - Precision - Analytic Sensitivity - Interferences - Stability - Reference Intervals and Medical Decision Points - References Postanalytic Considerations - Reporting Results - Quality Control Practices - Proficiency Testing - Ongoing Quality Assessments - Conclusion - References