The multitasking molecular chaperone Hsp60

Structure, function, and impact on health and disease

AvFrancesco Cappello,Everly Conway de Macario

Häftad, Engelska, 2024

1 642 kr

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Beskrivning

The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.

Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

Discusses strategies for diagnosis, patient monitoring, and treatment of disorders in which Hsp60 plays a role and can be used as biomarker and therapeutic target or agent
Explains the fundamental biophysics, genetics, physiology, and pathogenicity of Hsp60
Explores the mechanisms involving Hsp60 abnormalities causing disease, including carcinogenesis, inflammation, autoimmunity, and neurodegenerative disorders

Produktinformation

Utgivningsdatum:2024-10-24
Mått:152 x 229 x 15 mm
Vikt:520 g
Format:Häftad
Språk:Engelska
Antal sidor:324
Förlag:Elsevier Science
ISBN:9780443239960

Utforska kategorier

Biologi inom Naturvetenskap och teknik

Mer om författaren

Francesco Cappello is Full Professor of Anatomy and Histology at the University of Palermo, Palermo, Italy. He is also President of the Italian Society of Experimental Biology, Life member of the Cell Stress Society International and former Senior Editor of Cell Stress and Chaperones. He has been nominated “Adjunct Professor at the Temple University of Philadelphia (PA, USA) and at the University of Texas Medical Branch of Galveston (TX, USA). He has authored more than 300 scientific papers. Everly Conway de Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. She has written 320 articles, authored 1 book and edited 8 books. Dr. Conway de Macario’s research interests include the development of the concept of sick chaperone or chaperonopathy as a factor contributing to the ageing process and disease, elucidation of the entire set of hsp70 genes in the human genome, and characterization of the whole complement of cct-Hsp60 genes in the human genome. Alberto JL Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. He has authored 380 articles, is the author of 1 book, and editor of 7 books. Dr. Macario is also Group Leader at the Euro-Mediterranean Institute of Science and Technology, Palermo, Italy. His current interests are chaperonopathies pertaining to Hsp60, Hsp10, and CCT genes/proteins.

Innehållsförteckning

The chaperone system and its diseases: Introductory overview focusing on Hsp60Physical and biochemical properties of the molecular chaperone Hsp60The spectrum of human Hsp60 genetic variants and associated chaperonopathiesHsp60 in inflammation and autoimmunityHsp60 and carcinogenesisHsp60 involvement in articular cartilage tissue homeostasis and pathogenesisHsp60 and skeletal muscle diseasesHsp60 and cardiovascular diseasesHsp60 in physiology and pathophysiology of the respiratory systemHsp60 and diseases of the digestive systemThe chaperone system and the pathophysiology of the urogenital apparatus: Hsp60 rolesHsp60 and nervous system development and diseasesHsp60 and pathophysiology of the neuroendocrine systemHsp60 and artificial intelligence