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    1. Medicin
    2. Andra medicinska specialiteter
    3. Farmakologi

    Medicinal Chemistry and Drug Development

    AvGang Liu

    Häftad, Engelska, 2025

    2 612 kr

    Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacological
    properties of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.

    • Provides unique information on different drug development case studies
    • Integrates pharmaceutical knowledge-mainly medicinal chemistry-with new drug development thinking
    • Describes using case studies, the impact of key events in drug development and on drug efficacy

    Produktinformation

    • Utgivningsdatum:2025-02-05
    • Mått:216 x 276 x 38 mm
    • Vikt:2 170 g
    • Format:Häftad
    • Språk:Engelska
    • Antal sidor:804
    • Förlag:Elsevier Science
    • ISBN:9780443274022

    Utforska kategorier

    • Farmakologi inom Medicin

    Mer om författaren

    Professor Gang Liu has been engaged in research on medicinal chemistry and chemical biology for over 30 years. He studied at The Scripps Research Institute and the University of California, Davis in the United States. Since 2011, he has been a "Tenure-Track Professor" at Tsinghua University, Vice Dean of School of Medicine, and was responsible for the establishment of the Department of Pharmaceutical Sciences (now the School of Pharmaceutical Sciences) at Tsinghua University.

    Innehållsförteckning

    • 1. Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin2. The developmental history of insulin pharmaceuticals3. The developmental trajectory of GLP-1 receptor agonists4. Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors5. Cholesterol-lowering drug atorvastatin6. Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs7. Antithrombotic drug—apixaban8. Development of the anticoagulant drug fondaparinux sodium9. Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus10. The first HIV-1 integrase inhibitor, raltegravir11. Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir12. Baloxavir: an antiinfluenza drug with a novel mechanism of action13. Paclitaxel: a natural antitumor agent14. Antitumor drug eribulin15. Targeted protein kinase inhibitor imatinib16. A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitor—afatinib17. Medicinal chemistry and process development of the antibreast cancer drug tamoxifen18. Triazole antifungal drug—fluconazole19. Discovery of the antibacterial drug Linezolid and its synthetic technology research20. Carbapenem antibiotic meropenem21. Antiparasitic drug praziquantel22. A case study on the proton pump inhibitor omeprazole23. The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction24. GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs25. The discovery of risperidone: a case of multiple target antipsychotic drug26. A case study on the first-in-class antirenal anemia drug roxadustat27. Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (1)-calanolide A and its analogs28. Bisphosphonates: a targeted therapeutic medication for skeletal system29. Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs30. Case study of antisense oligonucleotides for duchenne muscular dystrophy