Réjean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Université de Montréal in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en santé du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University. He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.

• 1. Introduction to bradykininRéjean Couture2. Tracing the historical journey: milestones and highlights of bradykininRéjean Couture, Rahmeh Othman, Sébastien Talbot and Jean-Pierre Girolami3. Kinin receptors and their signaling and regulationFredrik Leeb-Lundberg4. Animal models for studying bradykinin receptorsLeonardo Martin, João Bosco Pesquero and Michael Bader5. Peptide and nonpeptide ligands acting at bradykinin receptorsFrançois Marceau, Xavier Charest-Morin and Lajos Gera6. Bradykinin-related peptides and their receptors from nonmammalian vertebratesHaixin Qin and Hang Fai Kwok7. Bradykinin forming pathways and the pathogenesis of hereditary angioedemaAllen P. Kaplan8. Bradykinin in ACEI and other drug-induced angioedemaNancy J Brown9. The kinins, a family of bioactive peptides that modulate inflammationCarlos D. Figueroa10. Bradykinin in painRobson da Costa, Marianne N. Manjavachi, Nara L.M. Quintão and Giselle F. Passos11. Bradykinin in cardiovascular physiology and diseaseFrançois Alhenc-Gelas, Nadine Bouby and Christine Richer-Giudicelli12. Tissue kallikrein in therapeutic angiogenesis: from basic science to clinical applicationsPaolo Roberto Madeddu13. Bradykinin in diabetes and obesityAlexandre Budu and Ronaldo Carvalho Araujo14. Bradykinin in ocular health and diseasesMenakshi Bhat, Réjean Couture and Elvire Vaucher15. Kinin agonists as a means to increase blood–brain barrier permeability of drugsJuliette Latulippe, David Fortin and Fernand Gobeil16. Bradykinin’s role in Alzheimer’s: protection or damage?Mariana Toricelli and Hudson Sousa Buck17. Bradykinin receptors in neglected parasitic and viral diseasesJulio Scharfstein18. Bradykinin in cancerGabriela Weirich Neculqueo and Maria Martha Campos

Réjean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Université de Montréal in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en santé du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University. He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.

• 1. Introduction to bradykininRéjean Couture2. Tracing the historical journey: milestones and highlights of bradykininRéjean Couture, Rahmeh Othman, Sébastien Talbot and Jean-Pierre Girolami3. Kinin receptors and their signaling and regulationFredrik Leeb-Lundberg4. Animal models for studying bradykinin receptorsLeonardo Martin, João Bosco Pesquero and Michael Bader5. Peptide and nonpeptide ligands acting at bradykinin receptorsFrançois Marceau, Xavier Charest-Morin and Lajos Gera6. Bradykinin-related peptides and their receptors from nonmammalian vertebratesHaixin Qin and Hang Fai Kwok7. Bradykinin forming pathways and the pathogenesis of hereditary angioedemaAllen P. Kaplan8. Bradykinin in ACEI and other drug-induced angioedemaNancy J Brown9. The kinins, a family of bioactive peptides that modulate inflammationCarlos D. Figueroa10. Bradykinin in painRobson da Costa, Marianne N. Manjavachi, Nara L.M. Quintão and Giselle F. Passos11. Bradykinin in cardiovascular physiology and diseaseFrançois Alhenc-Gelas, Nadine Bouby and Christine Richer-Giudicelli12. Tissue kallikrein in therapeutic angiogenesis: from basic science to clinical applicationsPaolo Roberto Madeddu13. Bradykinin in diabetes and obesityAlexandre Budu and Ronaldo Carvalho Araujo14. Bradykinin in ocular health and diseasesMenakshi Bhat, Réjean Couture and Elvire Vaucher15. Kinin agonists as a means to increase blood–brain barrier permeability of drugsJuliette Latulippe, David Fortin and Fernand Gobeil16. Bradykinin’s role in Alzheimer’s: protection or damage?Mariana Toricelli and Hudson Sousa Buck17. Bradykinin receptors in neglected parasitic and viral diseasesJulio Scharfstein18. Bradykinin in cancerGabriela Weirich Neculqueo and Maria Martha Campos

Réjean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Université de Montréal in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en santé du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University. He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.

• 1. Introduction to bradykininRéjean Couture2. Tracing the historical journey: milestones and highlights of bradykininRéjean Couture, Rahmeh Othman, Sébastien Talbot and Jean-Pierre Girolami3. Kinin receptors and their signaling and regulationFredrik Leeb-Lundberg4. Animal models for studying bradykinin receptorsLeonardo Martin, João Bosco Pesquero and Michael Bader5. Peptide and nonpeptide ligands acting at bradykinin receptorsFrançois Marceau, Xavier Charest-Morin and Lajos Gera6. Bradykinin-related peptides and their receptors from nonmammalian vertebratesHaixin Qin and Hang Fai Kwok7. Bradykinin forming pathways and the pathogenesis of hereditary angioedemaAllen P. Kaplan8. Bradykinin in ACEI and other drug-induced angioedemaNancy J Brown9. The kinins, a family of bioactive peptides that modulate inflammationCarlos D. Figueroa10. Bradykinin in painRobson da Costa, Marianne N. Manjavachi, Nara L.M. Quintão and Giselle F. Passos11. Bradykinin in cardiovascular physiology and diseaseFrançois Alhenc-Gelas, Nadine Bouby and Christine Richer-Giudicelli12. Tissue kallikrein in therapeutic angiogenesis: from basic science to clinical applicationsPaolo Roberto Madeddu13. Bradykinin in diabetes and obesityAlexandre Budu and Ronaldo Carvalho Araujo14. Bradykinin in ocular health and diseasesMenakshi Bhat, Réjean Couture and Elvire Vaucher15. Kinin agonists as a means to increase blood–brain barrier permeability of drugsJuliette Latulippe, David Fortin and Fernand Gobeil16. Bradykinin’s role in Alzheimer’s: protection or damage?Mariana Toricelli and Hudson Sousa Buck17. Bradykinin receptors in neglected parasitic and viral diseasesJulio Scharfstein18. Bradykinin in cancerGabriela Weirich Neculqueo and Maria Martha Campos