Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Sheila Spada is at Weill Cornell Medical College, NY, USA

• PrefaceSheila Spada and Lorenzo Galluzzi1. Circulating biomarkers for diagnosis and response to therapies in cancer patientsNatália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva,Laura Otto Walter, Maria Cláudia Santos-Silva, and Manas Ranjan Gartia2. Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patientsRonan W. Hsieh, Lynn K. Symonds, Jason Siu, and Stacey A. Cohen3. Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patientsPooja Ratre, Suresh Thareja, Pradyumna Kumar Mishra4. Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancerSabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha,M. Mujeeburahiman, and Chandrahas Koumar Ratnacaram5. Interleukin 10: Bridging the chasms in the immune landscape of multiple myelomaQueenie Fernandes, Abdul W. Ansari, Karama Makni-Maalej, Maysaloun Merhi,Said Dermime, Aamir Ahmad, and Shahab Uddin6. Nectin-4: A promising prognostic marker and therapeutic target in cancerShilpa Kuttikrishnan, Kirti S. Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M. Khan, Ajaz A. Bhat, and Shahab Uddi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Sheila Spada is at Weill Cornell Medical College, NY, USA

• PrefaceSheila Spada and Lorenzo Galluzzi1. Circulating biomarkers for diagnosis and response to therapies in cancer patientsNatália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva,Laura Otto Walter, Maria Cláudia Santos-Silva, and Manas Ranjan Gartia2. Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patientsRonan W. Hsieh, Lynn K. Symonds, Jason Siu, and Stacey A. Cohen3. Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patientsPooja Ratre, Suresh Thareja, Pradyumna Kumar Mishra4. Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancerSabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha,M. Mujeeburahiman, and Chandrahas Koumar Ratnacaram5. Interleukin 10: Bridging the chasms in the immune landscape of multiple myelomaQueenie Fernandes, Abdul W. Ansari, Karama Makni-Maalej, Maysaloun Merhi,Said Dermime, Aamir Ahmad, and Shahab Uddin6. Nectin-4: A promising prognostic marker and therapeutic target in cancerShilpa Kuttikrishnan, Kirti S. Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M. Khan, Ajaz A. Bhat, and Shahab Uddi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Sheila Spada is at Weill Cornell Medical College, NY, USA

• PrefaceSheila Spada and Lorenzo Galluzzi1. Circulating biomarkers for diagnosis and response to therapies in cancer patientsNatália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva,Laura Otto Walter, Maria Cláudia Santos-Silva, and Manas Ranjan Gartia2. Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patientsRonan W. Hsieh, Lynn K. Symonds, Jason Siu, and Stacey A. Cohen3. Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patientsPooja Ratre, Suresh Thareja, Pradyumna Kumar Mishra4. Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancerSabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha,M. Mujeeburahiman, and Chandrahas Koumar Ratnacaram5. Interleukin 10: Bridging the chasms in the immune landscape of multiple myelomaQueenie Fernandes, Abdul W. Ansari, Karama Makni-Maalej, Maysaloun Merhi,Said Dermime, Aamir Ahmad, and Shahab Uddin6. Nectin-4: A promising prognostic marker and therapeutic target in cancerShilpa Kuttikrishnan, Kirti S. Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M. Khan, Ajaz A. Bhat, and Shahab Uddi