Protein Misfolding and Human Diseases

Dr. Pranav Kumar Prabhakar is Professor and Head of the Department of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, India. His research focuses on elucidating molecular mechanisms involved in metabolic disorders, particularly diabetes, including strategies for oral insulin delivery and the use of natural products to mimic signaling pathways. He is a member of the Royal Society of Chemistry and the Asia-Pacific Chemical, Biological & Environmental Engineering Society. Dr. Prabhakar serves on the editorial boards of, and acts as a reviewer for, several national and international scientific journals. He has published extensively in his field and has contributed to numerous books and book chapters. He has also presented his research at scientific meetings and conferences. Dr. Ajit Prakash completed his B.Sc. Biotechnology at Jamia Millia Islamia, Delhi, and M.Sc. Genomics at Madurai Kamaraj University, Tamil Nadu, India. Further, Dr. Ajit obtained his Ph.D. in Biochemistry in 2016 from Nanyang Technological University, Singapore. He carried out his first postdoctoral fellowship at the University of Cambridge, UK. Following this he worked at Lovely Professional University as an assistant professor for almost a year and then finally relocated to the USA for his second postdoc at the University of North Carolina, Chaple Hill, USA. After 5 years of postdoctoral research at UNC, he is currently working as a Research Associate at UNC, Chapel Hill, USA. In addition to 3 book chapters and a book which are under publication, Dr. Ajit has published 16 high-impact research papers/book chapters in the fields of protein biochemistry, structural biology, and molecular biology related to disease conditions like cancer, and neurological disorders. Dr. Mohammad Ashhar Iqbal Khan is currently a Research Associate in the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill, USA. He completed his PhD in Biochemistry and Biophysics from the Indian Institute of Technology-Delhi in 2016. Dr. Khan's doctoral research focused on elucidating the molecular mechanisms of protein aggregation in neurodegenerative diseases like ALS and Parkinson's using biophysical techniques. As a postdoctoral researcher at UNC Chapel Hill and Lund University in Sweden, he expanded his expertise to study key cell adhesion proteins vinculin and metavinculin linked to cardiomyopathies and cancer. He has authored several peer-reviewed publications and delivered invited talks and poster presentations at scientific conferences. He is a recipient of prestigious fellowships and awards including the Erasmus Mundus Scholarship and the Carl Trygger Foundation Postdoctoral Scholarship. He serves as an editorial board member and reviewer for many reputed national and international journals.

• Part I: Fundamentals of protein aggregation1. Protein aggregation as a mechanistic consequence of proteostasis collapse and environmental‑biophysical interactionsPart II: Protein aggregation in neurodegenerative diseases2. Protein aggregation in amyotrophic lateral sclerosis3. Protein aggregation in prion diseases4. Protein aggregation in Huntington's disease5. Protein aggregation in Alzheimer's disease6. Protein aggregation in Parkinson's diseasePart III: Other protein aggregation diseases7. Systemic amyloidosis8. Protein aggregation and agingPart IV: Structural insights and therapeutic strategies9. Structural insights into pathological protein aggregates: from amyloid fibrils to inclusion bodies10. Therapeutic strategies against protein aggregation11. Recent advances in protein aggregation research and future outlook