Brain Shuttle Peptides: Development and Applications

Barbara Slusher is a Professor of Neurology (primary), Pharmacology and Molecular Sciences, Psychiatry, Neuroscience, Medicine, and Oncology at Johns Hopkins School of Medicine. She also serves as the Director of the Johns Hopkins Drug Discovery, the Vice Director of the Pedersen Brain Science Institute, and the Co-Director of the Johns Hopkins Center for the Advancement of HIV Neurotherapeutics (JH CAHN). She has published over 300 scientific articles and is an inventor on over100 patents and applications. Before joining Johns Hopkins, she spent 18 years in the pharmaceutical industry, including several years at the level of Senior Vice President of Research and Translational Development. She has extensive experience in drug discovery through early clinical development and was involved in the successful development, launch and/or post marketing support of several FDA-approved medicines. In 2010, she joined Johns Hopkins to lead the largest drug discovery program on campus with a veteran team of over 25 medicinal chemists, assay developers, pharmacologists, toxicologists, and pharmacokinetics/drug metabolism experts. The team identifies novel drug targets and translates them into new drug therapies for clinical development. Since joining JHU, she has co-founded four new companies which have amassed over $150M in financing and has partnered four new drug discovery programs with Pharma. She also founded the first International Consortium of Academic Drug Discovery Centers (http://addconsortium.org/) with over 150 university-led translational centers and 1500 members to bring together this growing community. Dr. Slusher received her undergraduate degree from Dickinson College where she graduated valedictorian, majoring in Chemistry. She received her Ph.D. in Pharmacology and Molecular Sciences from the Johns Hopkins School of Medicine while simultaneously earning her Master's degree in Administrative Science from the Johns Hopkins Carey School of Business (formerly School of Continuing Studies). Diane Peters is an Assistant Professor of Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine. She received her BA in Chemistry, with honors, from Wellesley College, followed by pursuit of a PhD in Pharmacology and Experimental Therapeutics from the Tufts University School of Medicine. Subsequently, she earned an MS in laboratory animal medicine as well as a doctorate of veterinary medicine, both granted by the Tufts University School of Veterinary Medicine. Dr. Peters performed her post-graduate fellowship training in laboratory animal medicine at the Johns Hopkins University School of Medicine, where she further refined research expertise in comparative medicine, translational drug discovery, and animal pharmacology/toxicology.

• 1. Introduction to brain shuttle peptidesBenjamí Oller-Salvia and Macarena Sánchez Navarro2. In silico optimization of brain shuttle properties for passive diffusionDaniela Kalafatovic, Patrizia Janković, Marko Njirjak, Nikolina Mohović and Ena Dražić3. Shuttles derived from natural proteinsToni Todorovski, Wadih Arap and Andrej Nikolić4. Shuttles derived from phage displayRenata Pasqualini5. Chemically enhanced brain shuttle peptidesCristina Díaz6. Brain delivery of gold nanoparticlesMarcelo Kogan7. Brain delivery of lipid nanoparticlesRonny Vargas-Monge, Noelia Martínez-Martínez, Laura Carrera-Rodríguez, Carlos Suñé and Marc Suñé-Pou8. Brain delivery of therapeutic proteinsMarina Plaza-Garrido9. In vitro BBB models for the study of brain shuttle transportFuzsina Walter10. Physiological strategies for delivery across the BBBDaniel Gonzalez Carter11. Polymeric NanoparticlesElena Sanchez Lopez