Barbara S. Slusher – författare

The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/development of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.Provides recent examples of successful academic drug discovery projects in multiple disease areas, including oncology, immunology, neurology, and infectious diseasesPresents diverse examples, including small molecule, biologic, and nanomedicine-based therapeuticsDiscusses innovative artificial intelligence platforms utilized in academic drug discovery efforts

Advances in Pharmacology, Volume 105, a new volume in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Introduction to brain shuttle peptides, In silico optimization of brain shuttle properties for passive diffusion, Shuttles derived from natural proteins, Shuttles derived from phage display, Chemically enhanced brain shuttle peptides, Brain delivery of gold nanoparticles, Brain delivery of lipid nanoparticles, Brain delivery of therapeutic proteins, In vitro BBB models for the study of brain shuttle transport, Physiological strategies for delivery across the BBB, and Polymeric Nanoparticles.Provides the latest information on PharmacologyOffers outstanding and original reviews on a range of Pharmacology research topicsServes as an indispensable reference for researchers and students alike

Pharmacology of T-Cell Therapies, Volume 106 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include Enhancing persistence of therapeutic T cells, T cell manufacturing impacts on in vivo function, Transient T cell therapies, In vivo T cell therapies, T cell subsets for therapy, Engineering T cell metabolism to enhance therapeutic efficacy, and Tracking Therapeutic T cells In Vivo contacts.Provides the latest information on pharmacology of T-cell therapiesOffers outstanding and original reviews on a range of pharmacology research topicsServes as an indispensable reference for researchers and students alike

The Pharmacology of Obesity, Volume 107 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Obesity Therapeutic Landscape, Challenges, and Unmet Needs, Diagnosis and Evaluation of Obesity for Therapeutic Selection, When to use First-Generation Anti-Obesity Medications?, GLP-1 Receptor Agonists in our Clinics, Future Directions in Obesity Pharmacotherapy: Novel Targets and Pipeline Therapies, Destigmatizing Obesity: from language to the clinical environment, and much more.Additional chapters cover Role of Nutrition and physical Activity in the Therapy of Obesity, Behavioral and Lifestyle Strategies in Obesity Management and Post-Bariatric Follow-Up, The interpretation of Body-composition Metrics in Obesity, Digital Health, Technology, Artificial Intelligence, and Wearables in Obesity Care, Metabolic Aging and Obesity: how Physiology Changes with Age, Endoscopic Bariatric and Metabolic Therapies, and What Patients Could Benefit from Bariatric Surgery?Provides the latest information on The pharmacology of obesityOffers outstanding and original reviews on a range of pharmacology research topicsServes as an indispensable reference for researchers and students alike