In this issue of Nursing Clinics of North America, guest editor Suellen Breakey brings her considerable expertise to the topic of The Impact of Climate Change on Health and Well-Being. Top experts discuss climate change as a public health and health equity issue that negatively impacts human health and well-being. This issue offers an up-to-date understanding of these myriad health consequences, providing nurses with the knowledge and skills to address these issues in individuals, communities, and populations by raising awareness, education, and advocacy.