CDK4/6 inhibitors in Breast Cancer Therapy

Dr. Pankaj Kumar Singh, Ph.D., is an Associate Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research-Hyderabad (NIPER-Hyderabad), India. He earned his Doctorate from CSIR-Central Drug Research Institute, Lucknow. He has authored more than 130 peer-reviewed publications in high-reputation international journals and contributed to over 64 book chapters. He holds 4 granted patents and has 5 patent applications filed on the area of drug delivery. He has supervised 7 PhD students and 38 MS students, and is currently guiding 9 PhD and 6 MS students on their dissertations and research projects. His research focuses on targeted drug delivery to cancer. Dr Singh's lab is actively involved in various scientific and socially impactful projects funded by prestigious organisations, including TSCOST-DBT, CCRUM, DST, ICMR, and the Department of Pharmaceuticals, Ministry of Chemicals and Fertilisers, Government of India. Manish K. Chourasia is the Chief Scientist in the Division of Pharmaceutics and Pharmacokinetics at CSIR Central Drug Research Institute (CDRI), Lucknow, India. He has played a significant role in advancing the field of nanoparticle-based drug delivery for breast cancer and neurodegenerative disorders, aiming to enhance the therapeutic outcome. Neelesh Kumar Mehra is an Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, India. He has authored more than 140 peer-reviewed publications in high-repute international journals, and has contributed to over 50 book chapters. He holds 4 granted patents and has 5 patent applications filed on manufacturing processes and compositions to improve therapeutic efficacy for drug delivery. He has supervised 5 PhD students and 36 MS students, and is currently guiding 10 PhD and 7 MS students on their dissertations and research projects. His research focuses on the design, development, and evaluation of ophthalmic nanoemulsions, liposomes, lipid-polymer nanoparticles, carbon nanoparticles, and chitosan/PLGA-lipid nanoparticles for drug and biomolecule delivery in biomedical applications. Dr. K. Gowthamarajan is a Professor & Head of the Department of Pharmaceutics at JSS College of Pharmacy, India. He holds a master’s (1996) and a Doctoral degree (2007) from Tamil Nadu Dr. MGR Medical University. With over 20 years in drug delivery research, he specializes in intranasal systems and personalized therapy. He has guided 50+ PG and 16 PhD students and secured various government research grants. An accomplished author with 150+ publications and 23 patents, he serves on multiple editorial boards and committees. He has received numerous awards, including the CV Raman International Fellowship.

• 1. CDK4/6 inhibitors: Drug discovery, development and classification2. CDK4/6 inhibitors: a medicinal chemistry, pharmacology, in-silico and drug delivery perspectives (SAR, LIGAND BINDING, SMALL MOLECULE, LIPINSKI RULE, PHYSICOCHEMICAL PROPERTIES)3. Molecular mechanism and mechanism of action of CDK4/6 inhibitors4. CDK4/6 inhibitors: clinical status, patent review and recent updates5. The neoteric paradigm of the use of CDK4/6 for breast cancer treatment as mono and adjuvant therapy6. The repurposing era of CDK4/6 in the treatment of various ailments7. Cytotoxic profile, molecular modelling, cell cycle arrest and apoptotic induction induced by CDK4/6 inhibitors8. The present-day means and challenges in the targeting of CDK4/6 inhibitors9. Market potential and post-marketing safety challenges of CDK4/6 inhibitors10. CDK4/6 inhibitors: future perspectives