Pankaj Kumar Singh – författare

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers.

The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling.

Presents exercises with solutions to aid readers in validating their own protocol Brings a thorough interpretation of results of each exercise to help readers compare them to their own study Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study

Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale

Innovative Targeting Strategies in Breast Cancer Therapy is a comprehensive reference addressing the challenge of non-specific drug distribution in the body, along with severe toxicity and adverse effects, by offering insights into targeted breast cancer treatment. It further educates researchers on formulating and developing novel carriers with target-specific attributes (such as targeted liposomes, nanoparticles, micelles, and dendrimers), contributing to a more refined approach to breast cancer. This book's content is presented in 12 chapters. The first chapters introduces the reader to the different breast cancer therapies followed by indepth information on targeting . Recognizing the need for targeted drug delivery in breast cancer treatment, this book presents an encompassing compilation of advanced research and formulation strategies. By focusing on effectively targeting cancer cells, the book mitigates dose-related toxicity associated with cytotoxic drugs, providing a comprehensive resource for improved treatment approaches. Research in oncology, pharmacology, medical researchers, biomedical engineers and clinical professionals will find this an essential reference.Delves into the intricacies of delivering drugs in cancer precisely to designated sites through molecular recognitionProvides in-depth coverage of existing market formulations, ongoing clinical trials, and intellectual property rights pertaining to targeted breast cancer therapiesOffers researchers up-to-date insights into breast cancer targeting strategies

CDK4/6 inhibitors in Breast Cancer Therapy examines the pivotal role of CDK4/6 inhibition in treating hormone receptor-positive (HR+)/HER2-negative advanced breast cancer. The book highlights FDA-approved applications of these inhibitors alongside endocrine therapy and explores ongoing research into their potential as neoadjuvant treatments. It provides insights into the drug discovery and development of CDK4/6 inhibitors, covering their molecular mechanisms, pharmacology, and clinical applications. Chapters address their use in mono and adjuvant therapies, as well as challenges in targeting, while also discussing market potential and post-marketing safety issues.This book is a valuable resource for researchers and academics, enhancing understanding of CDK4/6 inhibitors' chemistry and therapeutic implications. By presenting detailed information on clinical trials and market formulations, it equips the audience with essential knowledge to navigate the complexities of targeted breast cancer therapies and contributes to advancing research in this critical area.Provides comprehensive insights into drug discovery and development processes of CDK4/6 inhibitors, detailing the molecular mechanisms and pharmacological aspects relevant to targeted breast cancer therapyExplores the current clinical applications of CDK4/6 inhibitors, including their use in mono and adjuvant therapiesDiscusses market potential and the post-marketing safety issues associated with CDK4/6 inhibitors

This book recapitulates the significance of metal composites in modern sustainable industry, along with the critical review of process optimization techniques and tribological aspects for industrial and automotive applications.The book aims to cover all the topics relevant to the mechanical characteristics of metal matrix composites (MMCs) such as reinforcement types (particles, short fiber, and long or continuous fibers), their effect on the microstructure of composites, and significance in enhancing the materials’ mechanical and physical properties. The first two chapters aim to provide detailed learning about recent industrial advancements of diverse metal composites: aluminum, copper, and magnesium, and their significance in the modern workable industry. The next two chapters highlight a detailed analysis of particle, short-fiber, and continuous-fiber materials used for composite fabrication. Further chapters discuss the behavior of composites under various testing conditions, process optimization techniques, tribological technologies, lubrication knowledge including additives and lubricants, and improvements to the tribological properties of MMCs for industrial and automotive applications.Industrial Composites, Optimization Methods, and Tribological Considerations is an essential book for experts, scientists, and engineers who are involved in the domain of composite materials, tribology, and process optimization.

Feed additives are substances, preparations, and microorganisms that are added to animal feed to enhance growth performance, feed intake, and feed utilization efficiency for sustainable and cost-effective livestock production. This book, Animal Feed Additives, provides up-to-date information on the use of various animal feed additives in relation to the health, reproduction, and production of livestock and poultry. It contains 25 chapters written by 30 distinguished scientists in the field of animal nutrition, covering topics such as antioxidants, enzymes, probiotics, prebiotics, synbiotics, antimicrobials, organic acids, coccidiostats, mycotoxin binders, immunomodulators, hen egg antibody, hormones, beta agonists, methane inhibitors, defaunating agents, essential oils, and herbal feed additives.This book is designed to provide clear and accurate information on feed additives, supported by experimental evidence and references, making it a useful resource for students and researchers in the field of animal sciences, as well as teachers, scientists, feed industry personnel, field veterinarians, animal husbandry extension workers, and progressive animal farmers.

Forage refers to plant species that are either directly or indirectly consumed by animals. This book encompasses all theoretical and practical aspects of the conservation and utilization of forages as silage, hay, and haylage. It serves as a comprehensive resource for anyone seeking information on this topic.

Forage refers to plant species that are either directly or indirectly consumed by animals. This book provides comprehensive information on the theoretical and practical aspects of conserving and utilizing forages, including their use as silage, hay, and haylage.

The use of feed additives in animal feeds is a common practice in modern livestock production. These non-nutritive substances, preparations, and microorganisms are added to improve growth performance, feed intake, and the efficiency of feed utilization. This book, Animal Feed Additives, provides current information on the use of different animal feed additives for the production, health, and reproduction of livestock and poultry.Written by 30 eminent scientists in the field of animal nutrition, this book contains 25 chapters that highlight the significance of various feed additives, including antioxidants, enzymes, probiotics, prebiotics, synbiotics, antimicrobials, organic acids, coccidiostats, mycotoxin binders, immunomodulators, hen egg antibody, hormones, beta agonists, methane inhibitors, defaunating agents, essential oils, and herbal feed additives, among others. These feed additives are essential for sustainable livestock and poultry production and are supported by a good amount of experimental evidence and references.This book is an invaluable resource for students of animal sciences, teachers and scientists in the field of animal nutrition, personnel in the feed industry, field veterinarians, animal husbandry extension workers, and progressive animal farmers.